Noninvasive strategies in COVID-19: epistemology, randomised trials, guidelines, physiology
- PMID: 33303538
- PMCID: PMC7736749
- DOI: 10.1183/13993003.04247-2020
Noninvasive strategies in COVID-19: epistemology, randomised trials, guidelines, physiology
Abstract
Two recent ERJ articles demonstrate dramatic benefit with CPAP in COVID-19 patients, highlighting problems with the landmark trial of CPAP (and related guidelines) and illustrating the danger of believing that trials capture the truth of clinical practice
Conflict of interest statement
Conflict of interest: M.J. Tobin reports that he receives royalties for two books on critical care published by McGraw-Hill, Inc., New York. Conflict of interest: A. Jubran reports a grant from National Institute of Nursing Research (R01-NR016055) during the conduct of the study. Conflict of interest: F. Laghi reports a grant from Veterans Administration Research (1 I01 RX002803-01A1) during the conduct of the study.
Comment in
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Examining the intubation decision in randomised clinical trials.Eur Respir J. 2021 Mar 25;57(3):2100051. doi: 10.1183/13993003.00051-2021. Print 2021 Mar. Eur Respir J. 2021. PMID: 33767004 Free PMC article.
Comment on
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Continuous positive airway pressure in COVID-19 patients with moderate-to-severe respiratory failure.Eur Respir J. 2021 Feb 17;57(2):2002524. doi: 10.1183/13993003.02524-2020. Print 2021 Feb. Eur Respir J. 2021. PMID: 33033151 Free PMC article.
References
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- Rochwerg B, Brochard L, Elliott MW, et al. . Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J 2017; 50: 1602426. - PubMed
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- Delclaux C, L'Her E, Alberti C, et al. . Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask: a randomized controlled trial. JAMA 2000; 284: 2352–2360. - PubMed
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