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. 2020 Nov 16:12:585988.
doi: 10.3389/fnagi.2020.585988. eCollection 2020.

Effectiveness of an Innovative Cognitive Treatment and Telerehabilitation on Subjects With Mild Cognitive Impairment: A Multicenter, Randomized, Active-Controlled Study

Rosa Manenti  1 , Elena Gobbi  1 , Francesca Baglio  2 , Ambra Macis  3 , Clarissa Ferrari  3 , Ilaria Pagnoni  1 , Federica Rossetto  2 , Sonia Di Tella  2 , Federica Alemanno  4 , Vincenzo Cimino  5 , Giuliano Binetti  6 , Sandro Iannaccone  4 , Placido Bramanti  5 , Stefano F Cappa  7   8 , Maria Cotelli  1
Affiliations

Effectiveness of an Innovative Cognitive Treatment and Telerehabilitation on Subjects With Mild Cognitive Impairment: A Multicenter, Randomized, Active-Controlled Study

Rosa Manenti et al. Front Aging Neurosci. .

Abstract

Background: In recent years, the potential usefulness of cognitive training procedures in normal aging and mild cognitive impairment (MCI) have received increased attention.

Objective: The main aim of this study was to evaluate the efficacy of the face-to-face cognitive virtual reality rehabilitation system (VRRS) and to compare it to that of face-to-face cognitive treatment as usual for individuals with MCI. Moreover, we assessed the possibility of prolonging the effects of treatment with a telerehabilitation system.

Methods: A total of 49 subjects with MCI were assigned to 1 of 3 study groups in a randomized controlled trial design: (a) those who received face-to-face cognitive VRRS (12 sessions of individualized cognitive rehabilitation over 4 weeks) followed by telerehabilitation (36 sessions of home-based cognitive VRRS training, three sessions for week); (b) those who received face-to-face cognitive VRRS followed by at-home unstructured cognitive stimulation (36 sessions of home-based unstructured cognitive stimulation, three sessions for week); and (c) those who received face-to-face cognitive treatment as usual (12 sessions of face-to-face cognitive treatment as usual).

Results: An improvement in memory, language and visuo-constructional abilities was observed after the end of face-to-face VRRS treatment compared to face-to-face treatment as usual. The application of home-based cognitive VRRS telerehabilitation seems to induce more maintenance of the obtained gains than home-based unstructured stimulation.

Discussion: The present study provides preliminary evidence in support of individualized VRRS treatment and telerehabilitation delivery for cognitive rehabilitation and should pave the way for future studies aiming at identifying optimal cognitive treatment protocols in subjects with MCI.

Clinical trial registration: www.ClinicalTrials.gov, identifier NCT03486704.

Keywords: cognitive; dementia; home; mild cognitive impairment; telerehabilitation.

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Figures

FIGURE 1
FIGURE 1
Flow chart showing study subject enrollment and sample processing.
FIGURE 2
FIGURE 2
Effects of Face to Face cognitive VRRS (clinic-VRRS) vs. Face to Face cognitive treatment as Usual (clinic-TAU) on neuropsychological assessment. Asterisks indicate statistical significance.
FIGURE 3
FIGURE 3
Effects of home-based cognitive telerehabilitation (Tele@H-VRRS) vs. home-based unstructured cognitive stimulation (Tele@H-UCS) vs. no treatment on computerized cognitive tasks. Asterisks indicate statistical significance.
See this image and copyright information in PMC

References

    1. American Psychiatric Association (2014). DSM-5: Manuale Diagnostico e Statistico dei Disturbi Mentali. Milan: Raffaello Cortina editore.
    1. Antonietti A., Gandolla M., Rossini M., Molteni F., Pedrocchi A., Consortium A. (2016). “Interference between cognitive and motor recovery in elderly dementia patients through a holistic tele-rehabilitation platform,” in International Conference on Wireless Mobile Communication and Healthcare, Vol. 192 eds Perego P., Andreoni G., Rizzo G. (Cham: Springer; ), 359–366. 10.1007/978-3-319-58877-3_45 - DOI
    1. Astell A. J. (2019). Technology and dementia: the future is now. Dement. Geriatr. Cogn. Disord. 47 129–130. 10.1159/000497799 - DOI - PubMed
    1. Bangor A., Kortum P., Miller J. (2009). Determining what individual SUS scores mean: adding an adjective rating scale. J. Usability Stud. 4 114–123.
    1. Bangor A., Kortum P. T., Miller J. T. (2008). An empirical evaluation of the system usability scale. Int. J. Hum. Comput. Interact. 24 574–594. 10.1080/10447310802205776 - DOI

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