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. 2020 Nov 18:38:100819.
doi: 10.1016/j.nmni.2020.100819. eCollection 2020 Nov.

A child with soft-tissue infection and lymphadenitis

N J Froböse  1 , K Masjosthusmann  2 , S Huss  3 , C L Correa-Martinez  4 , A Mellmann  4 , F Schuler  1 , B C Kahl  1 , H Wittkowski  5 , F Schaumburg  1
Affiliations

A child with soft-tissue infection and lymphadenitis

N J Froböse et al. New Microbes New Infect. .

Abstract

We report a case of a soft-tissue infection with Francisella philomiragia, a rare opportunistic pathogen in individuals with chronic granulomatous disease.

Keywords: Chronic granulomatous disease; Francisella philomiragia; genetic relation; lymphadenitis; soft-tissue infections.

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Figures

Fig. 1
Fig. 1
Microbiological and histopathological aspects of Francisella philomiragia. (a) Greyish, translucent colonies of F. philomiragia on Columbia blood agar; (b) Gram-stain showing uneven Gram-negative coccobacilli; (c) hydrogen sulphide production (arrows) on triple sugar iron agar; (d) haematoxylin & eosin stain of axillar lymph node tissue showing granuloma with focal necrosis (arrows).
Fig. 2
Fig. 2
Neighbour-joining tree of Francisella philomiragia and closely related species based on 16S RNA gene sequences. The bootstrap values (500 replicates) are shown next to the branches. There were 980 positions in the final data set. Evolutionary analyses were conducted in MEGA [16].
See this image and copyright information in PMC

References

    1. European committee on antimicrobial susceptibility testing breakpoints tables for interpretation of MICs and zone diameters. 2020-01-01. Vol. 10.0. EUCAST; Växjö: 2020. pp. 107–110.
    1. M100—Performance standards for antimicrobial susceptibility testing. Clinical and Laboratory Standards Institute; 2020. https://www.clsi.org/standards/products/microbiology/documents/m100/ [Internet] - PMC - PubMed
    1. Mailman T., Schmidt M.H. Francisella philomiragia adenitis and pulmonary nodules in a child with chronic granulomatous disease. Can J Infect Dis Med Microbiol. 2005;16 - PMC - PubMed
    1. Hollis D., Weaver R., Steigerwalt A., Wenger J., Moss C., Brenner D. Francisella philomiragia comb. nov.(formerly Yersinia philomiragia) and Francisella tularensis biogroup novicida (formerly Francisella novicida) associated with human disease. J Clin Microbiol. 1989;27:1601–1608. - PMC - PubMed
    1. Wenger J.D., Hollis D.G., Weaver R.E., Baker C.N., Brown G.R., Brenner D.J. Infection caused by Francisella philomiragia (formerly Yersinia philomiragia) a newly recognized human pathogen. Ann Intern Med. 1989;110:888–892. - PubMed

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