Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jul;236(7):4807-4828.
doi: 10.1002/jcp.30204. Epub 2020 Dec 10.

The roles of liver X receptor α in inflammation and inflammation-associated diseases

Lin Zhao  1   2 , Wangrui Lei  1 , Chao Deng  3 , Zhen Wu  1 , Meng Sun  4 , Zhenxiao Jin  2 , Yanbin Song  5 , Zhi Yang  1 , Shuai Jiang  1 , Mingzhi Shen  6   7 , Yang Yang  1
Affiliations
Review

The roles of liver X receptor α in inflammation and inflammation-associated diseases

Lin Zhao et al. J Cell Physiol. 2021 Jul.

Abstract

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the nuclear receptor family of transcription factors and plays essential roles in the transcriptional control of cholesterol homeostasis. Previous in-depth phenotypic analyses of mouse models with deficient LXRα have also demonstrated various physiological functions of this receptor within inflammatory responses. LXRα activation exerts a combination of metabolic and anti-inflammatory actions resulting in the modulation and the amelioration of inflammatory disorders. The tight "repercussions" between LXRα and inflammation, as well as cholesterol homeostasis, have suggested that LXRα could be pharmacologically targeted in pathologies such as atherosclerosis, acute lung injury, and Alzheimer's disease. This review gives an overview of the recent advances in understanding the roles of LXRα in inflammation and inflammation-associated diseases, which will help in the design of future experimental researches on the potential of LXRα and advance the investigation of LXRα as pharmacological inflammatory targets.

Keywords: LXRs agonists; LXRα; cholesterol homeostasis; inflammation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Ahn, S. B., Jang, K., Jun, D. W., Lee, B. H., & Shin, K. J. (2014). Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease. Digestive Diseases and Sciences, 59(12), 2975-2982. https://doi.org/10.1007/s10620-014-3289-x
    1. Anthonisen, E. H., Berven, L., Holm, S., Nygård, M., Nebb, H. I., & Grønning-Wang, L. M. (2010). Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose. The Journal of Biological Chemistry, 285(3), 1607-1615. https://doi.org/10.1074/jbc.M109.082685
    1. Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M. A., Salbert, G., & Pfahl, M. (1994). A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Molecular and Cellular Biology, 14(10), 7025-7035. https://doi.org/10.1128/mcb.14.10.7025
    1. Baudoin, L., & Issad, T. (2014). O-GlcNAcylation and inflammation: A vast territory to explore. Frontiers in Endocrinology, 5, 235. https://doi.org/10.3389/fendo.2014.00235
    1. Becares, N., Gage, M. C., Voisin, M., Shrestha, E., Martin-Gutierrez, L., Liang, N., Louie, R., Pourcet, B., Pello, O. M., Luong, T. V., Goni, S., Pichardo-Almarza, C., Roberg-Larsen, H., Diaz-Zuccarini, V., Steffensen, K. R., O'Brien, A., Garabedian, M. J., Rombouts, K., Treuter, E., & Pineda-Torra, I. (2019). Impaired LXRalpha phosphorylation attenuates progression of fatty liver disease. Cell Reports, 26(4), 984-995. https://doi.org/10.1016/j.celrep.2018.12.094

Publication types

LinkOut - more resources