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. 2021 Jul;131(1):169-181.
doi: 10.1111/jam.14965. Epub 2020 Dec 23.

Antimicrobial resistance in Aeromonas species isolated from aquatic environments in Brazil

D Conte  1   2 , J K Palmeiro  1   2   3 , A A Bavaroski  1   2 , L S Rodrigues  1   2 , D Cardozo  4 , A P Tomaz  1   2   5 , J O Camargo  6   7 , L M Dalla-Costa  1   2
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Antimicrobial resistance in Aeromonas species isolated from aquatic environments in Brazil

D Conte et al. J Appl Microbiol. 2021 Jul.

Abstract

Aim: The current study was conducted to determine the antimicrobial resistance profile and genetic relatedness of Aeromonas sp. isolated from healthcare and urban effluents, wastewater treatment plant (WWTP) and river water.

Methods and results: We detected the presence of genes conferring resistance to β-lactam, quinolone and aminoglycoside. Multilocus sequence typing was carried out to differentiate the strains, and multilocus phylogenetic analysis was used to identify the species. A total of 28 cefotaxime-resistant Aeromonas sp. strains were identified, harbouring uncommon Guiana-extended-spectrum (GES)-type β-lactamases (GES-1, GES-5, GES-7 and GES-16). Multidrug-resistant Aeromonas sp. were found in hospital wastewater, WWTP and sanitary effluent, and A. caviae was identified as the most prevalent species (85·7%).

Conclusion: The release of untreated healthcare effluents, presence of antimicrobials in the environment, in addition to multidrug-resistant Aeromonas sp., are all potential factors for the spread of resistance.

Significance and impact of the study: We identified a vast repertoire of antimicrobial resistance genes (ARG) in Aeromonas sp. from diverse aquatic ecosystems, including those that encode enzymes degrading broad-spectrum antimicrobials widely used to treat healthcare-associated infections. Hospital and sanitary effluents serve as potential sources of bacteria harbouring ARG and are a threat to public health.

Keywords: Aeromonas species; GES-type; antimicrobial resistance; multilocus phylogenetic analysis; multilocus sequence typing; wastewater.

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