Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 1;64(1):20-25.
doi: 10.1097/GRF.0000000000000581.

Polycystic Ovarian Syndrome Genetics and Epigenetics

Joshua C Combs  1   2 , Micah J Hill  1   2 , Alan H Decherney  1
Affiliations

Polycystic Ovarian Syndrome Genetics and Epigenetics

Joshua C Combs et al. Clin Obstet Gynecol. .

Abstract

Polycystic ovarian syndrome and its associated endocrine abnormalities comprise one of the most common metabolic spectrum disorders within the human race. Because of the variance in phenotypic expression among individuals and within family lineages, attention has been turned to genetic and epigenetic changes in which the root cause of the disorder may lie. Further understanding of DNA/histone methylation and microRNA patterns may help to improve the accuracy of diagnosis and lead to future treatment options.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Promoter Genes identified by GWAS. (VNTR – Variable Number Tandem Repeats Insulin Gene; INSR – Insulin Receptor Gene; PPAR-Gama – Peroxisome Proliferator-Activated Receptor; FTO – Fat Mass/Obesity Gene; DENND1A – DENN Domain-containing Protein 1; LHCGR – Luteinizing Hormone/Chorionic Gonadotropin Receptor; THADA – Thyroid Adenoma-Associated Protein; TNF-Alpha – Tumor Necrosis Factor-Alpha; SHBG – Sex Hormone Binding Globulin).
Figure 2
Figure 2
MiRNAs and their associated pathophysiologic effects.
See this image and copyright information in PMC

References

    1. Azziz R, Introduction. Fertility and Sterility, 2016. 106(1): p. 4–5. - PubMed
    1. Trikudanathan S, Polycystic Ovarian Syndrome. Medical Clinics of North America, 2015. 99(1): p. 221–235. - PubMed
    1. Mukherjee S, Pathomechanisms of polycystic ovary syndrome Multidimensional approaches. Frontiers in Bioscience, 2018. 10(3): p. 384–422. - PubMed
    1. Filippou P and Homburg R, Is foetal hyperexposure to androgens a cause of PCOS? Human Reproduction Update, 2017. 23(4): p. 421–432. - PubMed
    1. Dumesic DA, et al., Mechanisms of intergenerational transmission of polycystic ovary syndrome. Reproduction, 2020. 159(1): p. R1–R13. - PMC - PubMed

Publication types