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. 2021 Mar 1;42(3):306-314.
doi: 10.1097/MNM.0000000000001337.

Prognostic value of imaging markers from 18FDG-PET/CT in paediatric patients with Hodgkin lymphoma

Mónica G Rodríguez Taroco  1 , Enrique G Cuña  1   2 , Carolina Pages  3 , Magdalena Schelotto  3 , Gabriel A González-Sprinberg  2 , Luis A Castillo  3 , Omar Alonso  1   4
Affiliations

Prognostic value of imaging markers from 18FDG-PET/CT in paediatric patients with Hodgkin lymphoma

Mónica G Rodríguez Taroco et al. Nucl Med Commun. .

Abstract

Objective: Identification of imaging prognostic parameters for early therapy personalisation to reduce treatment-related morbidity in paediatric Hodgkin lymphoma (HL). Our aim was to evaluate quantitative markers from baseline 2-[18F]fluoro-2-deoxy-d-glucose PET/CT as prognostic factors for treatment outcomes. Another goal was assessing the prognostic value of Deauville score at interim PET/CT.

Methods: Twenty-one patients were prospectively enrolled. Median age was 12 years (range 6-17); 13 were female. Patients underwent PET/CT for disease staging (bPET), at the end of two cycles of chemotherapy (iPET) and after chemotherapy. A total of 173 lesions were segmented from bPET. We calculated 51 texture features for each lesion. Total metabolic tumour volume and total lesion glycolysis from bPET were calculated for response prediction at iPET. Univariate and multivariate analyses were used for optimal cut-off values to separate responders at iPET according to the Deauville score.

Results: We identified four texture features as possible independent predictors of treatment outcomes at iPET. The areas under the ROC for univariate analysis were 0.89 (95% CI, 0.75-1), 0.82 (95% CI, 0.64-1), 0.79 (95% CI, 0.59-0.99) and 0.89 (95% CI, 0.75-1). The survival curves for patients assigned Deauville scores 1, 2, 3 and X were different from those assigned a score 4, with 4-year progression free-survival (PFS) rates of 85 versus 29%, respectively (P = 0.05).

Conclusions: We found four textural features as candidates for predicting early response to chemotherapy in paediatric patients with HL. The Deauville score at iPET was useful for differentiating PFS rates.

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References

    1. Mauz-Körholz C, Metzger ML, Kelly KM, Schwartz CL, Castellanos ME, Dieckmann K, et al. Pediatric Hodgkin Lymphoma. J Clin Oncol. 2015; 33:2975–2985.
    1. Bhakta N, Liu Q, Yeo F, Baassiri M, Ehrhardt MJ, Srivastava DK, et al. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkin’s lymphoma: an analysis from the St Jude Lifetime Cohort Study. Lancet Oncol. 2016; 17:1325–1334.
    1. Schellong G, Riepenhausen M, Ehlert K, Brämswig J, Dörffel W, Schmutzler RK, et al. Brest cancer in young women after treatment for Hodgkin’s disease during childhood or adolescence. Dtsch Ärztebl Int. 2014; 111:3–9.
    1. Bhatia S, Yasui Y, Robison LL, Birch JM, Bogue MK, Diller L, et al.; Late Effects Study Group. High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin’s disease: report from the Late Effects Study Group. J Clin Oncol. 2003; 21:4386–4394.
    1. Gotti M, Fiaccadori V, Bono E, Landini B, Varettoni M, Arcaini L, et al. Therapy-related late adverse events in Hodgkin’s lymphoma. Lymphoma. 2013; 2013:1–7.

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