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. 2021 Apr;110(4):1201-1208.
doi: 10.1111/apa.15715. Epub 2020 Dec 20.

Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017-a population-based study

Karin Konzett  1   2   3 , David Riedl  4 , Carmen Stark  1 , Burkhard Simma  1
Affiliations

Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017-a population-based study

Karin Konzett et al. Acta Paediatr. 2021 Apr.

Abstract

Aim: The study compares neurodevelopmental outcome at 24 months corrected age of very preterm infants exposed to chorioamnionitis and controls. Peripartal parameters which may influence outcome are also investigated.

Methods: In this observational population-based study, very preterm infants born between 2007 and 2017 were eligible (n = 466) and included if a histological placental examination and a complete neurodevelopmental assessment (Bayley Scale of Infant Development II or III) (n = 168) were performed. Secondary analyses were calculated to identify peripartal factors that significantly influence mental and psychomotor outcome.

Results: Included infants showed a mean MDI of 91.2 (SD = 20.7) and a mean PDI of 99.4 (SD = 14.8). Infants with (n = 71) and without (n = 97) chorioamnionitis did not statistically differ either with mean MDI (91.8 vs. 90.3 points; p = 0.29) or mean PDI (98.3 vs. 100.9 points; p = 0.81), even after controlling for gestational age, mean APGAR scores and administration of antenatal steroids. Bronchopulmonary dysplasia was identified as the most influential factor for both MDI (p = .024) and PDI (p = .004).

Conclusion: We could not find an effect of chorioamnionitis on neurodevelopmental outcome of very preterm infants over an eleven-year period. Analysis shows that postnatal factors have higher impacts than does chorioamnionitis.

Keywords: bayley scale of infant development; chorioamnionitis; neurodevelopmental outcome; very preterm infants.

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References

REFERENCES

    1. Statistik Austria. Frühgeborene seit 1984. 2020
    1. Adams-Chapman I, Heyne RJ, DeMauro SB, et al. Neurodevelopmental impairment among extremely preterm infants in the neonatal research network. Pediatrics. 2018;141(5):e20173091
    1. Soraisham AS, Singhal N, McMillan DD, Sauve RS, Lee SK. A multicenter study on the clinical outcome of chorioamnionitis in preterm infants. Am J Obstet Gynecol. 2009;200(4):372.e1-372.e6.
    1. Pappas A, Kendrick DE, Shankaran S, et al. Chorioamnionitis and Early Childhood Outcomes Among Extremely Low-Gestational-Age Neonates. JAMA Pediatr. 2014;168(2):137-147.
    1. Maisonneuve E, Ancel PY, Foix-L’Hélias L, Marret S, Kayem G. Impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in preterm infants: A literature review. Gynecol Obstet Hum Reprod. 2017;46(4):307-316.

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