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Review
. 2020 Dec;67(4S):S147-S154.
doi: 10.1016/j.ijtb.2020.06.004. Epub 2020 Jul 3.

Hydroxychloroquine and COVID-19 - A narrative review

Jyoti Bajpai  1 , Akshyaya Pradhan  2 , Abhishek Singh  3 , Surya Kant  4
Affiliations
Review

Hydroxychloroquine and COVID-19 - A narrative review

Jyoti Bajpai et al. Indian J Tuberc. 2020 Dec.

Abstract

COVID 19 infection is unarguably the worst pandemic of this century. Till date there is no promising drug and vaccine available to treat this deadly viral infection. In the early phase chloroquine phosphate and hydroxychloroquine sulphate have been used to fight this illness on the basis of handful observational and small randomized and small-randomized studies. The paucity of clinical evidences of an unequivocal beneficial effect of chloroquine and hydroxychloroquine on COVID-19 has resulted in the passionate use of the drug for moderate to severe cases only and stimulated the need for large clinical trials for this and other molecules. In this review, we describe in brief the mechanism of action, the clinical studies, factors for cardiac toxicity, guidelines and future directions for hydroxychloroquine use in management of COVID-19 infection.

Keywords: COVID-19; Hydroxychloroquine; Immunomodulator; Pandemic; QT prolongation.

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Conflict of interest statement

Conflicts of interest The authors have none to declare.

Figures

Fig. 1
Fig. 1
Commonly used drugs causing QT interval prolongation on ECG.
See this image and copyright information in PMC

References

    1. Coronavirus Disease (COVID-19)- Situation Report 116 : World Health Organization. 2020. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situatio... Available form:
    1. Sanders J.M., Monogue M.L., Jodlowski T.Z., Cutrell J.B. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. J Am Med Assoc. 2020 doi: 10.1001/jama.2020.6019. available online April 13, 2020. - DOI - PubMed
    1. National Health Commission of the People’s Republic of China . Feb 19, 2020. Interpretation of COVID-19 Treatment Guidelines (6th Version)http://www.gov.cn/zhengce/2020-02/19/content_5480958.htm (accessed April 2020, 2020; in Chinese)
    1. Sahraei Z., Shabani M., Shokouhi S., Saffaei A. Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine. Int J Antimicrob Agents. 2020:105945. - PMC - PubMed
    1. Riou B., Barriot P., Rimailho A., Baud F.J. Treatment of severe chloroquine poisoning. N Engl J Med. 1988;318:1–6. - PubMed

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