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. 2020 Dec 11;3(1):159.
doi: 10.1038/s41746-020-00370-8.

Characteristics and challenges of the clinical pipeline of digital therapeutics

Nisarg A Patel  1   2 , Atul J Butte  3
Affiliations

Characteristics and challenges of the clinical pipeline of digital therapeutics

Nisarg A Patel et al. NPJ Digit Med. .

Abstract

In this Comment, we characterize the current pipeline of digital therapeutics and offer a clinical perspective into the advantages, challenges, and barriers to implementation of this treatment modality for patient care, which we hope will inform future regulatory policy, prescribing decisions, and scope of real-world evidence collection.

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Conflict of interest statement

N.A.P. is a cofounder of and shareholder in Memora Health Inc. and receives personal fees as a consultant for Bessemer Venture Partners. A.J.B. is a cofounder of and consultant to Personalis and NuMedii; consultant to Samsung, Geisinger Health, Mango Tree Corp., Regenstrief Institute, and, in the recent past, 10x Genomics and Helix; shareholder in NuMedii and Personalis; and minor shareholder in Apple, Facebook, Google, Microsoft, 10x Genomics, Amazon, Biogen, Regeneron, Moderna, Illumina, Snap, Sutro, Sanofi, and several other non-health-related companies and mutual funds. He has received honoraria and travel reimbursement for invited talks from Genentech, Roche, Pfizer, Merck, Lilly, Mars, Siemens, Optum, AbbVie, Westat, and many academic institutions, medical or disease-specific foundations and associations, and health systems. AJB receives royalty payments through Stanford University for several patents (US20160018413, WO2013169751, US2013039918, US20130080068, US20130116931, US20130090909, US20120101736, WO2011094731, and US20130071408) and other disclosures licensed to NuMedii and Personalis and Carmenta (now Progenity). AJB’s research has been funded by Northrop Grumman (as the prime on an NIH contract), Genentech, and, in the recent past, L’Oréal and Progenity.

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