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Review
. 2020 Dec 1:14:1179546820977196.
doi: 10.1177/1179546820977196. eCollection 2020.

A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease

Samarthkumar Thakkar  1 , Shilpkumar Arora  2 , Ashish Kumar  3 , Rahul Jaswaney  4 , Mohammed Faisaluddin  5 , Mohammad Ammad Ud Din  1 , Mariam Shariff  3 , Kirolos Barssoum  1 , Harsh P Patel  6 , Arora Nirav  7 , Chinmay Jani  8 , Kripa Patel  9 , Sejal Savani  10 , Christopher DeSimone  11 , Siva Mulpuru  11 , Abhishek Deshmukh  11
Affiliations
Review

A Systematic Review of the Cardiovascular Manifestations and Outcomes in the Setting of Coronavirus-19 Disease

Samarthkumar Thakkar et al. Clin Med Insights Cardiol. .

Abstract

The impact of coronavirus disease, 2019 (COVID-19), has been profound. Though COVID-19 primarily affects the respiratory system, it has also been associated with a wide range of cardiovascular (CV) manifestations portending extremely poor prognosis. The principal hypothesis for CV involvement is through direct myocardial infection and systemic inflammation. We conducted a systematic review of the current literature to provide a foundation for understanding the CV manifestations and outcomes of COVID-19. PubMed and EMBASE databases were electronically searched from the inception of the databases through 27 April 2020. A second literature review was conducted to include major trials and guidelines that were published after the initial search but before submission. The inclusion criteria for studies to be eligible were case reports, case series, and observation studies reporting CV outcomes among patients with COVID-19 infection. This review of the current COVID-19 disease and CV outcomes literature revealed a myriad of CV manifestations with potential avenues for treatment and prevention. Future studies are required to understand on a more mechanistic level the effect of COVID-19 on the myocardium and thus provide avenues to improve mortality and morbidity.

Keywords: COVID-19; CV outcomes; acute coronary syndrome; myocarditis; stroke; thrombosis.

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Conflict of interest statement

Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA flow chart for studies inclusion.
Figure 2.
Figure 2.
Summary of major cardiovascular manifestations in COVID-19.
See this image and copyright information in PMC

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