Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Dec 4;16(2):338-342.
doi: 10.1016/j.radcr.2020.11.029. eCollection 2021 Feb.

Pulmonary and intracranial miliary tuberculosis secondary to Behçet's anti-TNF alfa treatment

Asmae Sekkat  1 , Siham Bouchal  2 , Yahya Charifi  1 , Khalid El Hajjam  1 , Youssef Lamrani Alaoui  1 , Mohammed Faouzi Belahsen  2 , Mustapha Maaroufi  1 , Badr Alami  1
Affiliations
Case Reports

Pulmonary and intracranial miliary tuberculosis secondary to Behçet's anti-TNF alfa treatment

Asmae Sekkat et al. Radiol Case Rep. .

Abstract

Behçet disease is a rare vasculitis that affects vessels of different body parts, causing different kinds of manifestations. We report a case of a 47 years old woman who had a tumor necrosis factor alfa blocker prescription due to a Behçet's disease relapse. The patient then developed a cerebral and pulmonary tuberculous miliary due to immunodeficiency. The aim of this work is to show that tuberculosis infection is a common complication of the administration of tumor necrosis factor alfa blocker, and the importance to perform a tuberculosis screening before starting the treatment.

Keywords: Anti-TNF alfa; Behçet's disease; Immunodeficiency; Miliary; Tuberculosis.

PubMed Disclaimer

Figures

Fig 1 –
Fig. 1
Axial unenhanced chest CT scan images showing several micronodules, uniformly distributed throughout the lung (hematogenous distribution), related to a tuberculous miliary.
Fig 2 –
Fig. 2
Multiple punctiform and nodular supra and infratentorial parenchymal lesions, predominant at the grey-white matter junction, with mild hypersignal on T2 WI (a, b) and FLAIR (c, d), enhanced after contrast (e, f).
Fig 3 –
Fig. 3
Filling defect of the left transverse sinus (a), extended towards the sigmoid sinus (b) and the homolateral jugular vein (c).
See this image and copyright information in PMC

References

    1. Kone-Paut I, Barete S, Bodaghi B, Deiva K, Desbois A-C, Galeotti C, et al. Protocole National de Diagnostic et de Soins sur la Maladie de Behçet. Les « recommandations de bonne pratique ». HAS - Haute Autorité de Santé. 2020
    1. Chae EJ, Do K-H, Seo JB, Park SH, Kang J-W, Jang YM. Radiologic and clinical findings of Behçet disease: comprehensive review of multisystemic involvement. Radiographics. 2008;28:e31. doi: 10.1148/rg.e31. - DOI - PubMed
    1. Alami B, Boujraf S, Quenum L, Alaoui Lamrani MY, Haloua M, Boubbou M. Cerebral venous thrombosis: clinical and radiological features, about 62 cases. J Med Vasc. 2019;44:387–399. - PubMed
    1. Zuber J-P, Bart P-A, Leimgruber A, Spertini F. Maladie de Behçet: d'Hippocrate aux antagonites du TNF-alpha. Revue médicale suisse. 2008;4:1045–1054. - PubMed
    1. Keane J, Gershon S, Wise RP, Mirabile-Levens E, Kasznica J, Schwieterman WD. Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent. N Engl J Med. 2001;345:1098–1104. - PubMed

Publication types

LinkOut - more resources