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. 2020 Oct 13;7(12):001981.
doi: 10.12890/2020_001981. eCollection 2020.

The Relationship of Cholangiocarcinoma with Human Immunodeficiency Virus Cholangiopathy and Cytomegalovirus Infection

Arda Yavuz  1 , Rabia Burçin Girgin  2 , İlyas Tuncer  1
Affiliations

The Relationship of Cholangiocarcinoma with Human Immunodeficiency Virus Cholangiopathy and Cytomegalovirus Infection

Arda Yavuz et al. Eur J Case Rep Intern Med. .

Abstract

Human immunodeficiency virus (HIV) is a worldwide disease with an increasing number of cases globally. Initially, HIV cholangiopathy was often observed among such patients but has become rare after three decades because of the availability of new treatment options and potent antiretroviral drugs. Consequently, its occurrence now suggests drug resistance or disease progression. The relationship between cholangiocarcinoma and HIV remains unclear. We report the case of a patient with high-grade dysplasia of the ductus choledochus and uncontrolled disease which was treated with potent antiviral agents and bile duct dilatation.

Learning points: HIV cholangiopathy should be kept in mind in an HIV-positive patient even if they are receiving combination antiretroviral therapy (cART); endoscopic retrograde cholangiopancreatography can provide symptomatic relief.Once HIV cholangiopathy is detected, close follow-up for cholangiocarcinoma is required.Opportunistic infections can cause cholangiocarcinoma in HIV-positive patients.

Keywords: Hepatosteatosis; late-onset lipid storage myopathy; lipid storage disease.

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Conflict of interest statement

Conflicts of Interests: The Authors declare that there are no competing interests.

Figures

Figure 1
Figure 1
A. Magnetic resonance cholangiopancreatography showing bile duct dilation. B. PET-CT scan showing tracer uptake in the papilla tumour. C. PET-CT scan showing lumbar spinal metastasis
Figure 2
Figure 2
A. Normal duodenal epithelium. B. High grade dysplasia (H&E, ×40)
See this image and copyright information in PMC

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