Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 5;6(1):e12072.
doi: 10.1002/trc2.12072. eCollection 2020.

Development and validation of language and visuospatial composite scores in ADNI

Seo-Eun Choi  1 , Shubhabrata Mukherjee  1 , Laura E Gibbons  1 , R Elizabeth Sanders  1 , Richard N Jones  2 , Douglas Tommet  2 , Jesse Mez  3 , Emily H Trittschuh  4   5 , Andrew Saykin  6 , Melissa Lamar  7 , Laura Rabin  8 , Nancy S Foldi  9 , Sietske Sikkes  10 , Roos J Jutten  10 , Evan Grandoit  11 , Christine Mac Donald  12 , Shannon Risacher  6 , Colin Groot  10 , Rik Ossenkoppele  10   13 ; Alzheimer's Disease Neuroimaging Initiative; Paul K Crane  1
Affiliations

Development and validation of language and visuospatial composite scores in ADNI

Seo-Eun Choi et al. Alzheimers Dement (N Y). .

Abstract

Introduction: Composite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults.

Methods: We used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress.

Results: ADNI-Lan and ADNI-VS were able to detect change over time and predict conversion from MCI to AD. They were associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern.

Discussion: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.

Keywords: Alzheimer's Disease Neuroimaging Initiative; cognition; language; longitudinal analysis; magnetic resonance imaging; psychometrics; visuospatial functioning.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

References

    1. Lezak MD. Neuropsychological Assessment. 3 ed. NY: Oxford University Press; 1995.
    1. Boada M, Lopez O, Nunez L, et al. Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: study design and progress. Alzheimers Dement (N Y). 2019;5:61‐69. - PMC - PubMed
    1. Ho JK, Nation DA. Neuropsychological profiles and trajectories in preclinical Alzheimer's disease. J Int Neuropsychol Soc. 2018;24:693‐702. - PMC - PubMed
    1. Mandal PK, Joshi J, Saharan S. Visuospatial perception: an emerging biomarker for Alzheimer's disease. J Alzheimers Dis. 2012;31(Suppl 3):S117‐35. - PubMed
    1. McCullough KC, Bayles KA, Bouldin ED. Language performance of individuals at risk for mild cognitive impairment. J Speech Lang Hear Res. 2019;62:706‐722. - PubMed

LinkOut - more resources