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. 2021 Jun;30(6):716-726.
doi: 10.1002/pds.5184. Epub 2020 Dec 27.

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

Sophie van den Broek  1   2 , Angela Lupattelli  1 , Anna S Frank  1 , Line Småstuen Haug  3 , Hedvig Nordeng  1   4
Affiliations

Thyroid hormone replacement therapy in pregnancy and motor function, communication skills, and behavior of preschool children: The Norwegian Mother, Father, and Child Cohort Study

Sophie van den Broek et al. Pharmacoepidemiol Drug Saf. 2021 Jun.

Abstract

Purpose: Limited research has focused on the association between prenatal thyroid hormone replacement therapy (THRT) and motor function, communication skills, and behavior in preschool children. Here, we estimated the association between THRT during pregnancy and the first trimester and these developmental outcomes.

Methods: This study was based on the Norwegian Mother, Father, and Child Cohort Study (MoBa) and other national registries. We included mother-child pairs exposed to THRT during pregnancy (n = 663), after delivery (n = 728), or unexposed (n = 28 040). Exposure to THRT was defined according to filled prescriptions. Child outcomes, presented as T-score differences, were parent-reported using the Ages and Stages Questionnaire, Strengths and Difficulties Questionnaire, and Child Behavior Checklist.

Results: Of 29 431 mother-child pairs, 2.3% were prenatally exposed to THRT. We found no difference between prenatally exposed and unexposed children in regards to gross motor function (β: 0.17, 95% CI -1.19, 1.54), fine motor function (β: -0.17, 95% CI -1.14, 0.80), communication (β: -0.31, 95% CI -1.58, 0.96), externalizing (β: -0.03, 95% CI -1.07, 1.01), internalizing (β: 0.89, 95% CI -0.20, 1.97), or social behaviors (β: -0.04, 95% CI -0.92, 0.84). Somatic complaints were higher in THRT-exposed children (β: 0.98, 95% CI 0.08, 1.87), and children whose mothers were exposed after delivery had more sleep problems than unexposed children (β: 0.99, 95% CI 0.24, 1.74).

Conclusions: Children prenatally exposed to THRT have developmental outcomes as positive as unexposed children on motor function, communication, and behavior. The association with somatic complaints and sleep were not clinically relevant.

Keywords: MoBa; behavior; communication; hypothyroidism; motor function; pregnancy.

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Conflict of interest statement

The authors declare no conflict of interest. This paper is original and has never been presented or posted anywhere else.

Figures

FIGURE 1
FIGURE 1
Flow chart of the study population.Abbreviations: MoBa=Norwegian Mother, Father and Child Cohort Study, MoBa Q1=MoBa questionnaire 1, MoBa 3=MoBa questionnaire 3, MBRN=Medical Birth Registry of Norway, NorPD=Norwegian Prescription Database, Q6=MoBa questionnaire 6, ASQ=Ages and Stages Questionnaire, SDQ=Strengths and Difficulties Questionnaire, CBCL=Child Behavior Checklist, THRT=thyroid hormone replacement therapy
See this image and copyright information in PMC

References

    1. Jefferys A, Vanderpump M, Yasmin E. Thyroid dysfunction and reproductive health. Obstet Gynaecol. 2015;17(1):39‐45.
    1. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18(3):404‐433. - PubMed
    1. Moreno‐Reyes R, Glinoer D, Van Oyen H, Vandevijvere S. High prevalence of thyroid disorders in pregnant women in a mildly iodine‐deficient country: a population‐based study. J Clin Endocrinol Metab. 2013;98(9):3694‐3701. - PubMed
    1. Leung AM. Thyroid function in pregnancy. J Trace Elem Med Biol. 2012;26(2–3):137‐140. - PMC - PubMed
    1. Forhead AJ, Fowden AL. Thyroid hormones in fetal growth and prepartum maturation. J Endocrinol. 2014;221(3):R87‐r103. - PubMed

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