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. 2021 Aug 1;41(8):1762-1770.
doi: 10.1097/IAE.0000000000003067.

CHOROIDAL NEOVASCULARIZATION SECONDARY TO PHOTODYNAMIC THERAPY FOR CENTRAL SEROUS CHORIORETINOPATHY: Incidence, Risk Factors, and Clinical Outcomes

Sungsoon Hwang  1 , Hoon Noh, Se Woong Kang, Min Chae Kang, Dongyoung Lee, Sang Jin Kim
Affiliations

CHOROIDAL NEOVASCULARIZATION SECONDARY TO PHOTODYNAMIC THERAPY FOR CENTRAL SEROUS CHORIORETINOPATHY: Incidence, Risk Factors, and Clinical Outcomes

Sungsoon Hwang et al. Retina. .

Abstract

Purpose: To investigate the incidence, risk factors, and clinical outcomes of complicated choroidal neovascularization (CNV) after reduced-fluence photodynamic therapy (PDT) for central serous chorioretinopathy.

Methods: This is a retrospective consecutive interventional study including 559 eyes from 520 patients treated by reduced-fluence PDT for central serous chorioretinopathy. The incidence of complicated CNV within 3 months after PDT was calculated. Baseline demographics and ocular findings were investigated to identify risk factors. The clinical course of complicated CNV was analyzed.

Results: Seven cases experienced development of active CNV after PDT within 3 months with a median interval of 4 weeks (range, 2-12 weeks). The incidence was estimated as 1.25% (95% CI, 0.55-2.62%). Complicated CNV developed in 6 among 138 eyes (4.35%) with flat irregular pigment epithelial detachment and in 1 among 421 eyes (0.24%) without flat irregular pigment epithelial detachment (P < 0.001, Fisher's exact test). The median best-corrected visual acuity recovered from 20/100 at the time of CNV development to 20/20 after anti-vascular endothelial growth factor injections (median, 3 times).

Conclusion: In approximately 1%, reduced-fluence PDT for central serous chorioretinopathy may be complicated by CNV, which can be well controlled with anti-vascular endothelial growth factor injection. Flat irregular pigment epithelial detachment increases the risk of secondary CNV following PDT.

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Comment in

  • Correspondence.
    Tombolini B, Sacconi R, Querques G. Tombolini B, et al. Retina. 2022 Aug 1;42(8):e38-e39. doi: 10.1097/IAE.0000000000003553. Retina. 2022. PMID: 35877971 No abstract available.
  • Reply.
    Hwang S, Kang SW, Kang MC, Lee D. Hwang S, et al. Retina. 2022 Aug 1;42(8):e39-e40. doi: 10.1097/IAE.0000000000003554. Retina. 2022. PMID: 35877972 No abstract available.

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