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. 2021 Jan 1;86(1):970-979.
doi: 10.1021/acs.joc.0c02463. Epub 2020 Dec 15.

Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp

Mingyu Liu  1   2 , Pinglin Li  1   2 , Xuli Tang  3 , Xiangchao Luo  1   2 , Kechun Liu  4 , Yun Zhang  4 , Qi Wang  1   2   5 , Guoqiang Li  1   2
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Lemnardosinanes A-I: New Bioactive Sesquiterpenoids from Soft Coral Lemnalia sp

Mingyu Liu et al. J Org Chem. .

Abstract

Two rearranged nardosinane sesquiterpenoids with novel carbon skeletons, lemnardosinanes A (1) and B (2), and seven new nardosinane-related sesquiterpeniod lemnardosinanes C-I (3-9), together with a known compound 6,7-seco-13-nornardosinan (10), were isolated from the soft coral Lemnalia sp. collected from Xisha Islands of the South China Sea. Their structures were elucidated by comprehensive spectroscopic analyses, Mosher's method, Mo2(OAc)4-induced circular dichroism experiment, and quantum chemical calculations. Plausible biosynthetic pathways of 1-10 were proposed. Compounds 1 and 10 displayed in vivo angiogenesis promoting activity in a zebrafish model. Compounds 3 and 4 exhibited antiviral activity against the H1N1 virus with IC50 values of 10.9 and 41.5 μM, respectively.

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