Review
doi: 10.1016/0268-960x(87)90021-x.
The value of indium-labelled leucocytes in clinical practice
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- PMID: 3332088
- DOI: 10.1016/0268-960x(87)90021-x
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Review
The value of indium-labelled leucocytes in clinical practice
Blood Rev.
1987 Mar.
Abstract
Following intravenous injection, autologous 111In labelled-leucocytes migrate to sites of inflammation, where they can be imaged with the gamma camera. The principle underlining the labelling technique is exposure of a population of leucocytes or purified granulocytes to a lipophilic 111In complex, such as 111In oxine or 111In tropolonate. As a result of cell activation, the in vitro manipulation to which the leucocytes are subjected modifies their biodistribution early after re-injection. Separation and labelling in plasma-enriched media, however, limits this activation and promotes early migration into inflammatory foci.
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