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. 2020 Dec 15;10(12):e042819.
doi: 10.1136/bmjopen-2020-042819.

Antimicrobial use across six referral hospitals in Tanzania: a point prevalence survey

Jeremiah Seni  1 , Siana G Mapunjo  2 , Rachel Wittenauer  3 , Richard Valimba  4 , Andy Stergachis  3   5 , Brian J Werth  5 , Samir Saitoti  6 , Noel H Mhadu  2 , Edgar Lusaya  4 , Niranjan Konduri  7
Affiliations

Antimicrobial use across six referral hospitals in Tanzania: a point prevalence survey

Jeremiah Seni et al. BMJ Open. .

Abstract

Objective: To delineate the prevalence and factors associated with antimicrobial use across six referral hospitals in Tanzania using WHO point prevalence survey (PPS) methodology to inform hospital-specific antimicrobial stewardship programmes.

Design: Cross-sectional analytical study.

Setting: Six referral hospitals in Tanzania.

Participants: Patients irrespective of age and gender (n=948) admitted in the six referral hospital wards before 8:00 hours on each day of the survey were included in December 2019. Using the WHO PPS methodology, data on hospitals, wards, patients, antibiotics, and indications for antibiotics were collected.

Outcome measures: We analysed the prevalence of antibiotic use by referral hospital, ward, indication and patient characteristics as the main outcomes. We also described adherence to the Tanzania Standard Treatment Guidelines (STG) and WHO's AWaRe categorisation of antibiotics.

Results: Approximately 62.3% of inpatients were prescribed antibiotics, predominantly from the Access group of antibiotics (ceftriaxone, metronidazole or ampicillin-cloxacillin). The overall adherence of antibiotic prescriptions to the Tanzania STG was high (84.0%), with the exception of Sekou Toure Regional Referral Hospital (68.0%) and Maweni Regional Referral Hospital (57.8%). The most common indication for antibiotic prescriptions was community-acquired infections (39.8%). Children less than 2 years of age (OR 1.73, 95% CI 1.02 to 2.92, p=0.039); admission to surgical wards (OR 4.90, 95% CI 2.87 to 8.36, p <0.001); and admission to paediatric wards (OR 3.93, 95% CI 2.16 to 7.15, p <0.001) were associated with increased odds of antibiotic use. Only 2 of 591 patients were prescribed antibiotics based on culture and antimicrobial susceptibility testing results.

Conclusions: Empirical use of antibiotics is common, and the Access group of antibiotics is predominantly prescribed in children less than 2 years and patients admitted to surgical and paediatric wards. Lack of utilisation of antimicrobial susceptibility testing services in these hospitals requires urgent interventions. Routine monitoring of antibiotic use is recommended to be part of antibiotic stewardship programmes in Tanzania.

Keywords: pharmacology; public health; tropical medicine.

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Conflict of interest statement

Competing interests: BJW has received grant support from commercial sources, including Shionogi Inc. All other authors declare to have no any competing interests.

Figures

Figure 1
Figure 1
Proportions of antibiotic use across six referral hospitals. RRH, regional referral hospital; ZRH, zonal referral hospital.
See this image and copyright information in PMC

References

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