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Review
. 2020 Dec 8:16:3023-3033.
doi: 10.2147/NDT.S282384. eCollection 2020.

Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression

Yuan Wang  1 , Miao Peng  1
Affiliations
Review

Research Progress on Classical Traditional Chinese Medicine Jieyu Pills in the Treatment of Depression

Yuan Wang et al. Neuropsychiatr Dis Treat. .

Abstract

Depression is a common clinical psychological disease, which is called "yu zheng" in traditional Chinese medicine (TCM). TCM has a long history in the treatment of depression (yu zheng), which has unique advantages. Jieyu pill (JYP), a classical TCM formula, has been widely used for treating depression because of its clear clinical efficacy, low side effects, and high compliance. In this review, we systematically introduce recent clinical and animal experimental studies on JYP and depression, and review the pharmacological mechanism and active ingredients of JYP, as well as its clinical application in depression therapy. This systematic review provides a deep understanding of TCM prescriptions, pharmacological mechanisms, and disease-medicine interactions, and lays the foundation for developing new treatments for depression.

Keywords: Jieyu pill; active ingredient; depression disorder; pharmacology; yu zheng.

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Conflict of interest statement

The authors declare that they have no competing interests for this work.

Figures

Figure 1
Figure 1
The 2D structures of effective biomarkers in JYP (JYP, Jieyu pill).
Figure 2
Figure 2
A total of 12 targets of both JYP and depression were identified.
Figure 3
Figure 3
A total of 12 targets were used to establish the regulatory network in Cytoscape.
Figure 4
Figure 4
Network of enriched terms: (A) colored by cluster ID, where nodes that share the same cluster ID are typically close to each other; (B) colored by p-value, where terms containing more genes tend to have a more significant p-value.
See this image and copyright information in PMC

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