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Comment
. 2020 Dec 15;53(6):1128-1130.
doi: 10.1016/j.immuni.2020.11.008.

Paying a Price Twice: Dose-Dependent Effects of Treg Cell-Derived TGF- β on Tolerance

Hailey Brown  1 , Daria Esterházy  2
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Paying a Price Twice: Dose-Dependent Effects of Treg Cell-Derived TGF- β on Tolerance

Hailey Brown et al. Immunity. .
Free article

Abstract

Although many immune cells can secrete TGF-β, whether all sources of TGF-β are functionally equivalent is unknown. In this issue, Turner et al. uncover the importance of T regulatory (Treg) cell-intrinsic Tgfb1 gene dose in the prevention of autoimmunity and allergic disease.

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