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. 2020 Dec 15;33(11):108507.
doi: 10.1016/j.celrep.2020.108507.

Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice

Levi Todd  1 , Connor Finkbeiner  1 , Claire K Wong  1 , Marcus J Hooper  1 , Thomas A Reh  2
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Free article

Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice

Levi Todd et al. Cell Rep. .
Free article

Abstract

The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that in mice, microglia inhibit the Ascl1-mediated retinal regeneration, suggesting that the innate immune system limits the regenerative response to injury.

Keywords: Muller glia; glia; glial reprogramming; microglia; neurogenesis; regeneration; retina; retinal inflammation.

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Conflict of interest statement

Declaration of Interests A patent for the use of Ascl1 and additional factors has been filed for by the University of Washington with inventors T.A.R., Nikolas Jorstad, and L.T. The patent is titled “Methods and compositions for reprogramming Müller glia.”

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