Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 11;99(50):e23213.
doi: 10.1097/MD.0000000000023213.

Cryptococcosis caused by cryptococcus gattii: 2 case reports and literature review

Xinying Xue  1 , Hui Deng  1 , Longting Zhao  2 , Xuelei Zang  3 , Idorenyin Polycarp Asuquo  4 , Mingming Meng  5 , Xidong Ma  6 , Chong Qin  1 , Yao Meng  7 , Chongchong Wu  8 , Jie Gao  9 , Lei Pan  1
Affiliations
Review

Cryptococcosis caused by cryptococcus gattii: 2 case reports and literature review

Xinying Xue et al. Medicine (Baltimore). .

Abstract

Cryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating illness in both immunocompetent and immunocompromised individuals. Cryptococcosis due to C. gattii is a serious systemic fungal infection, with pulmonary central nervous system tropism. Epidemiologically, C. gattii infection is not only restricted in tropical and subtropical regions, but also in other geographical settings.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interests to disclose.

Figures

Figure 1
Figure 1
(A) Irregular nodule with spicules and lobulation in the periphery of the lungs in CT. (B) Pathological scanning of excised mass. (C) Histology demonstrated numerous encapsulated yeasts with clear halos were scattered in the necrotic tissue and granuloma.
See this image and copyright information in PMC

References

    1. Chayakulkeeree M, Perfect JR. Cryptococcosis. Infect Dis Clin North Am 2006;20:507–44. v-vi. PubMed PMID: 16984867. Epub 2006/09/21. eng. - PubMed
    1. Chen SC, Meyer W, Sorrell TC. Cryptococcus gattii infections. Clin Microbiol Rev 2014;27:980–1024. PubMed PMID: 25278580. PMCID: 4187630. Epub 2014/10/04. eng. - PMC - PubMed
    1. Hagen F, Khayhan K, Theelen B, et al. Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex. Fungal Genet Biol 2015;78:16–48. PubMed PMID: 25721988. Epub 2015/02/28. eng. - PubMed
    1. Harris J, Lockhart S, Chiller T. Cryptococcus gattii: where do we go from here? Med Mycol 2012;50:113–29. PubMed PMID: 21939343. Epub 2011/09/24. eng. - PubMed
    1. Fyfe M, MacDougall L, Romney M, et al. Cryptococcus gattii infections on Vancouver Island, British Columbia, Canada: emergence of a tropical fungus in a temperate environment. Can Commun Dis Rep 2008;34:1–2. PubMed PMID: 18802986. Epub 2008/09/20. eng fre. - PubMed

MeSH terms