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Review
. 2021 Jun 3;17(6):1787-1802.
doi: 10.1080/21645515.2020.1844525. Epub 2020 Dec 17.

Update on rotavirus vaccine underperformance in low- to middle-income countries and next-generation vaccines

Benjamin Lee  1
Affiliations
Review

Update on rotavirus vaccine underperformance in low- to middle-income countries and next-generation vaccines

Benjamin Lee. Hum Vaccin Immunother. .

Abstract

In the decade since oral rotavirus vaccines (ORV) were recommended by the World Health Organization for universal inclusion in all national immunization programs, significant yet incomplete progress has been made toward reducing the burden of rotavirus in low- to middle-income countries (LMIC). ORVs continue to demonstrate effectiveness and impact in LMIC, yet numerous factors hinder optimal performance and evaluation of these vaccines. This review will provide an update on ORV performance in LMIC, the increasing body of literature regarding factors that affect ORV response, and the status of newer and next-generation rotavirus vaccines as of early 2020. Fully closing the gap in rotavirus prevention between LMIC and high-income countries will likely require a multifaceted approach accounting for biological and methodological challenges and evaluation and roll-out of newer and next-generation vaccines.

Keywords: Rotavirus; developing countries; low- to middle-income countries; oral vaccine; rotavirus vaccines; vaccine performance.

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Conflict of interest statement

The author has no conflicts of interest to disclose.

References

    1. Troeger C, Khalil IA, Rao PC, Cao S, Blacker BF, Ahmed T, Armah G, Bines JE, Brewer TG, Colombara DV, et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr. 2018;172:958–65. doi:10.1001/jamapediatrics.2018.1960. - DOI - PMC - PubMed
    1. Liu J, Platts-Mills JA, Juma J, Kabir F, Nkeze J, Okoi C, Operario DJ, Uddin J, Ahmed S, Alonso PL, et al. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study. Lancet. 2016;388(10051):1291–301. doi:10.1016/S0140-6736(16)31529-X. - DOI - PMC - PubMed
    1. Platts-Mills JA, Liu J, Rogawski ET, Kabir F, Lertsethtakarn P, Siguas M, Khan SS, Praharaj I, Murei A, Nshama R, et al. Use of quantitative molecular diagnostic methods to assess the aetiology, burden, and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study. Lancet Glob Health. 2018;6(12):e1309–e18. doi:10.1016/S2214-109X(18)30349-8. - DOI - PMC - PubMed
    1. Clark A, Black R, Tate J, Roose A, Kotloff K, Lam D, Blackwelder W, Parashar U, Lanata C, Kang G, et al. Estimating global, regional and national rotavirus deaths in children aged <5 years: current approaches, new analyses and proposed improvements. PLoS One. 2017;12:e0183392. - PMC - PubMed
    1. Tate JE, Burton AH, Boschi-Pinto C, Parashar UD.. World health organization-coordinated global rotavirus surveillance N. Global, regional, and national estimates of rotavirus mortality in children <5 years of age, 2000-2013. Clin Infect Dis. 2016;62:S96–S105. - PMC - PubMed

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