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Comment
. 2021 Mar;18(3):518-519.
doi: 10.1038/s41423-020-00606-3. Epub 2020 Dec 17.

Monocyte-derived KCs (MoKCs) contribute to the KC pool in NASH

Yingchun Wang  1 , Lifen Gao  2
Affiliations
Comment

Monocyte-derived KCs (MoKCs) contribute to the KC pool in NASH

Yingchun Wang et al. Cell Mol Immunol. 2021 Mar.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Permanent changes in the KC pool during NASH progression. Defined as Clec4f+, Cd163+, Timd4+, and Vsig4+ cells, EmKCs take up the KC pool in healthy livers. Owing to their appropriate response to lipid and toxic SFA conversion ability, the liver maintains homeostasis. However, under steatohepatitis conditions, EmKCs might die from lipid-induced stress. Simultaneously, MoKCs contribute to the KC pool. In contrast to EmKCs, MoKCs poorly express Timd4 and CD163 and alter the liver response to lipid overload, exhibiting more hyperproliferative and inflammatory traits. Moreover, during steatohepatitis regression, MoKCs remain for a long time and represent 40–50% of the KC pool. With elevated expression of Vsig4 and Timd4, they acquire a more mature phenotype
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