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Comment
. 2021 Mar;17(3):131-132.
doi: 10.1038/s41584-020-00563-1.

Unravelling the complex genetic regulation of immune cells

Paula S Ramos  1
Affiliations
Comment

Unravelling the complex genetic regulation of immune cells

Paula S Ramos. Nat Rev Rheumatol. 2021 Mar.

Abstract

Genetic variation contributes to immune cell function. An unprecedented analysis of genetic associations with immune cell traits provides insights into the complex regulation of immune cells, reveals variants that coincidently influence immune traits and autoimmune disease risk, and offers specific therapeutic targets for these diseases.

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  • Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.
    Orrù V, Steri M, Sidore C, Marongiu M, Serra V, Olla S, Sole G, Lai S, Dei M, Mulas A, Virdis F, Piras MG, Lobina M, Marongiu M, Pitzalis M, Deidda F, Loizedda A, Onano S, Zoledziewska M, Sawcer S, Devoto M, Gorospe M, Abecasis GR, Floris M, Pala M, Schlessinger D, Fiorillo E, Cucca F. Orrù V, et al. Nat Genet. 2020 Oct;52(10):1036-1045. doi: 10.1038/s41588-020-0684-4. Epub 2020 Sep 14. Nat Genet. 2020. PMID: 32929287 Free PMC article.

References

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