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. 2020 Nov 19:11:595005.
doi: 10.3389/fphys.2020.595005. eCollection 2020.

Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction

Hasnae Benkirane  1 , Jaafar Heikel  2 , Fatima Zahra Laamiri  3 , Amina Bouziani  1 , Houria Lahmam  1 , Ayoub Al-Jawaldeh  4 , Noureddine El Haloui  1 , Khalid Ennibi  5 , Naim Akhtar-Khan  6 , El Mostafa El Fahime  7 , Majdouline Obtel  8 , Amina Barkat  9 , Hassan Aguenaou  1
Affiliations

Study of Clinical and Biological Characteristics of Moroccan Covid-19 Patients With and Without Olfactory and/or Gustatory Dysfunction

Hasnae Benkirane et al. Front Physiol. .

Abstract

Background: The epidemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), presents a significant and urgent threat to global health. This alarming viral infection, declared as pandemic by the WHO in February 2020, has resulted millions of infected patients and thousands of deaths around the world. In Morocco, despite the efforts made by the authorities, the SARS-CoV-2 continues to spread and constitutes a burden of morbidity and mortality. The objective of this study is to describe clinical characteristics of COVID-19 Moroccan patients and to establish the relationship between specific clinical symptoms, namely ageusia and/or anosmia, with these characteristics.

Methods: We performed a descriptive, non-interventional cross-sectional study analyzing data from 108 patients admitted to the VINCI clinic, Casablanca (Morocco). The database includes 39 parameters including epidemiological characteristics, anthropometric measurements and biological analyzes.

Results: The average of age of the patients was 43.80 ± 15.75 years with a sex ratio of 1:1. The mean body mass index of the patients was 25.54 ± 4.63 Kg/m2. The majority of patients had, at least, one comorbidity and among 75% symptomatic patients, about 50% had, at least, three symptoms namely, fever (40.7%), cough (39.8%), myalgia (28.7%), and anosmia and/or ageusia (20.4%). From biological analyzes, we noticed lymphopenia and an elevated protein C reactive and lactate dehydrogenases levels in 24.1, 36.1, and 35.2% of patients, respectively. A disturbance in liver function markers was observed in 15.7% of cases. For the other hemostasis parameters, high levels of prothrombin and platelets were reported in 14.6 and 14.8% of patients, respectively. Comparisons related to the presence of anosmia and/or ageusia did not show any difference for demographic and anthropometric characteristics, while a possibility of a significant difference was revealed for certain biological parameters, particularly the levels of lymphocytes, D-dimer and troponin.

Conclusion: This study provides significant findings that will be used not only to supplement previous studies carried out in Morocco in order to resume the epidemiological situation in comparison with other countries, but also to improve the quality of the diagnosis of COVID-19 patients by identifying all the symptoms of the disease and better understanding its clinical outcomes.

Keywords: COVID-19; Moroccan patients; ageusia; anosmia; biological; demographic characteristics; epidemiological.

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References

    1. Arentz M., Yim E., Klaff L., et al. (2020). Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington Statejama. JAMA 323 1612–1614. 10.1001/jama.4326 - DOI - PMC - PubMed
    1. Arthur S., Chetboun M., Poissy J., Raverdy V., Noulette J., Duhame A., et al. (2020). High Prevalence of Obesity in Severe Acute RespiratorySyndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity 28 1195–1199. 10.1002/oby.22831 - DOI - PMC - PubMed
    1. Baig A. M., Khaleeq A., Ali U., Syeda H. (2020). Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 11 995–998. 10.1021/acschemneuro.0c00122 - DOI - PubMed
    1. Baik I., Curhan G. C., Rimm E. B., Bendich A., Willett W. C., Fawzi W. W. (2000). A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women Arch. Intern. Med. 160 3082–3308. 10.1001/archinte.160.20.3082 - DOI - PubMed
    1. Bermejo-Martin J. F., Almansa R., Menéndez R., Mendez R., Kelvin D. J., Torres A. (2020). Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection: Lymphopenia in severe COVID-19 infection. J. Infect. 80:e23–e24. 10.1016/j.jinf.2020.02.029 - DOI - PMC - PubMed