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Review
. 2020 Nov 30:11:618801.
doi: 10.3389/fimmu.2020.618801. eCollection 2020.

Flavivirus Infection and Regulation of Host Immune and Tissue Homeostasis in Insects

Sneh Harsh  1   2 , Ioannis Eleftherianos  1
Affiliations
Review

Flavivirus Infection and Regulation of Host Immune and Tissue Homeostasis in Insects

Sneh Harsh et al. Front Immunol. .
No abstract available

Keywords: Drosophila; flavivirus; homeostasis; immunity; mosquito; pathophysiology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Zika virus and host pathologies in Drosophila. Zika virus results in perturbed homeostasis of different organs in Drosophila larva and adult. (A) Overexpression of Zika virus NS4A results in microcephaly in brain and restricted growth of the wing and eye imaginal epithelia. In the wing and eye imaginal epithelia, Zika virus NS4A interacts with Notch and JAK/STAT signaling pathways while in case of the brain, Zika virus NS4A targets ANKLE2, a highly conserved mitotic regulator. (B) Infection of Zika virus in Drosophila adult flies results in perturbed intestinal and adipose tissue homeostasis marked by increased intestinal stem cell proliferation and increased size of the lipid droplets.
See this image and copyright information in PMC

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