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Review
. 2020 Nov 30:10:596359.
doi: 10.3389/fonc.2020.596359. eCollection 2020.

MicroRNA Signature in Renal Cell Carcinoma

Soudeh Ghafouri-Fard  1 , Zeinab Shirvani-Farsani  2 , Wojciech Branicki  3 , Mohammad Taheri  4
Affiliations
Review

MicroRNA Signature in Renal Cell Carcinoma

Soudeh Ghafouri-Fard et al. Front Oncol. .

Abstract

Renal cell carcinoma (RCC) includes 2.2% of all diagnosed cancers and 1.8% of cancer-related mortalities. The available biomarkers or screening methods for RCC suffer from lack of sensitivity or high cost, necessitating identification of novel biomarkers that facilitate early diagnosis of this cancer especially in the susceptible individuals. MicroRNAs (miRNAs) have several advantageous properties that potentiate them as biomarkers for cancer detection. Expression profile of miRNAs has been assessed in biological samples from RCC patients. Circulatory or urinary levels of certain miRNAs have been proposed as markers for RCC diagnosis or follow-up. Moreover, expression profile of some miRNAs has been correlated with response to chemotherapy, immunotherapy or targeted therapeutic options such as sunitinib. In the current study, we summarize the results of studies that assessed the application of miRNAs as biomarkers, therapeutic targets or modulators of response to treatment modalities in RCC patients.

Keywords: biomarker; cancer; expression; miRNA; renal cell carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The schematic depiction of the interplay between miRNAs and tumor-suppressive gene PTEN in renal cell cancer. MiR-22 and miR-203 are decreased, while miR-301 and miR-193a-3p are up-regulated in RCC. miRNA expression changes result in reducing the expression of PTEN. Consequently, cell proliferation, invasive behavior, and migration are enhanced in RCC.
See this image and copyright information in PMC

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