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Review
. 2020 Nov 30:10:614907.
doi: 10.3389/fonc.2020.614907. eCollection 2020.

Towards Personalization in the Curative Treatment of Gastric Cancer

Astrid E Slagter  1 , Marieke A Vollebergh  2 , Edwin P M Jansen  1 , Johanna W van Sandick  3 , Annemieke Cats  2 , Nicole C T van Grieken  4 , Marcel Verheij  1   5
Affiliations
Review

Towards Personalization in the Curative Treatment of Gastric Cancer

Astrid E Slagter et al. Front Oncol. .

Abstract

Gastric cancer is the fifth most common cancer worldwide and has a high mortality rate. In the last decades, treatment strategy has shifted from an exclusive surgical approach to a multidisciplinary strategy. Treatment options for patients with resectable gastric cancer as recommended by different worldwide guidelines, include perioperative chemotherapy, pre- or postoperative chemoradiotherapy and postoperative chemotherapy. Although gastric cancer is a heterogeneous disease with respect to patient-, tumor-, and molecular characteristics, the current standard of care is still according to a one-size-fits-all approach. In this review, we discuss the background of the different treatment strategies in resectable gastric cancer including the current standard, the specific role of radiotherapy, and describe the current areas of research and potential strategies for personalization of therapy.

Keywords: future perspectives; gastric cancer; multidisciplinary approach; personalization; radiation oncology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Timeline of different practice-changing randomized trials (–31).
Figure 2
Figure 2
Timeline of different randomized trials that have not led to change of clinical practice (yet) in the curative setting, but have investigated important research questions and/or form the rationale behind ongoing (possibly practice changing) studies (46, 47, 49, 77, 90, 103).
See this image and copyright information in PMC

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