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. 2020 Dec 9:75:e2360.
doi: 10.6061/clinics/2020/e2360. eCollection 2020.

Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil

Carla Solange Escórcio-Dourado  1 , Francisco Adelton Alves-Ribeiro  1 , Jose Charles Lima-Dourado  1 , Alesse Ribeiro Dos Santos  1 , Renato de Oliveira Pereira  1 , Cleciton Braga Tavares  1 , Vladimir Costa Silva  1 , Pedro Vitor Lopes Costa  2 , José Maria Soares-Júnior  3 , Benedito Borges da Silva  1   2
Affiliations

Human Epidermal Growth Factor Receptor-2 gene polymorphism and breast cancer risk in women from the Northeastern region of Brazil

Carla Solange Escórcio-Dourado et al. Clinics (Sao Paulo). .

Abstract

Objectives: In the Human Epidermal Growth Factor Receptor-2 (HER2) rs1136201 variant, the presence of the G allele may promote cellular alterations and increase breast cancer risk, in addition to enhanced cellular proliferation, tumor aggressiveness, and metastases. The aim of this study was to investigate the presence of the single-nucleotide polymorphism (SNP) variant, rs1136201, within the HER2 gene in women from the Northeastern region of Brazil and breast cancer risk.

Methods: The study included 140 women who were divided into two groups, case (breast cancer) and control (without breast cancer), with 70 women in each group. Peripheral blood of each woman was drawn for the study of genomic Deoxyribonucleic acid (DNA) extracted from leukocytes using the genotyping technique by real-time polymerase chain reaction.

Results: The GG genotype occurred in 1 woman in both groups (1.4%) (p=0.32), while the AG genotype occurred in 19 (27.2%) and 13 (18.6%) women in the case and control (p=1.00) groups, respectively. No statistically significant difference in GG and AG genotypes was observed between the case and control groups in premenopausal women (p=1.00). Furthermore, no significant difference in genotypes was observed between the groups, among postmenopausal women (p=0.14).

Conclusion: In this study, the HER2 rs1136201 polymorphism did not show any statistically significant association with breast cancer, both in premenopausal and postmenopausal women. Nevertheless, further studies with a larger sample size should be performed to assess the association of HER2 polymorphism with breast cancer risk in women from the Northeastern region of Brazil.

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Conflict of interest statement

No potential conflict of interest was reported.

References

    1. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piãeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144(8):1941–53. doi: 10.1002/ijc.31937. - DOI - PubMed
    1. Borges US, Costa-Silva DR, da Silva-Sampaio JP, Escórcio-Dourado CS, Conde AM, Jr, Campelo V, et al. A comparative study of Ki-67 antigen expression between luminal A and triple-negative subtypes of breast cancer. Med Oncol. 2017;34(9):156. doi: 10.1007/s12032-017-1019-x. - DOI - PubMed
    1. Barros-Oliveira MDC, Costa-Silva DR, Campos-Verdes LC, Pereira RO, Silva RA, Moura-Borges PT, et al. CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse. BMC Cancer. 2020;20(1):480. doi: 10.1186/s12885-020-06978-z. - DOI - PMC - PubMed
    1. Quintanilha LF, Souza LN, Sanches D, Demarco RS, Fukutani KF. The impact of cancer campaigns in Brazil: a Google Trends analysis. Ecancermedicalscience. 2019;13:963. doi: 10.3332/ecancer.2019.963. - DOI - PMC - PubMed
    1. Estimate/2020 - Incidence of Cancer in Brazil. National Cancer Institute. https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//....