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Meta-Analysis
. 2020 Dec 9;54(2):e10366.
doi: 10.1590/1414-431X202010366. eCollection 2020.

Association between matrix metalloproteinase-1 (MMP-1) protein level and the risk of rheumatoid arthritis and osteoarthritis: a meta-analysis

Maopeng Wang  1 , You Zhou  1 , Wei Huang  1 , Yong Zeng  1 , Xinzhi Li  1
Affiliations
Meta-Analysis

Association between matrix metalloproteinase-1 (MMP-1) protein level and the risk of rheumatoid arthritis and osteoarthritis: a meta-analysis

Maopeng Wang et al. Braz J Med Biol Res. .

Abstract

Recent publications have investigated the potential role of the protein level of matrix metalloproteinase-1 (MMP-1) in the susceptibility to rheumatoid arthritis (RA) and osteoarthritis (OA). However, no unanimous conclusion was obtained. Therefore, we carried out a meta-analysis to explore the association between MMP-1 expression and these two clinical disorders. After database searching and screening, we enrolled a total of eighteen articles for the pooled analysis. We observed a significant association between RA cases and controls in the whole population [SMD (standard mean difference)=1.01, P=0.017]. There were similar positive results in the subgroup analysis of "population-based control" (SMD=1.50, P=0.032) and "synovial fluid" (SMD=1.32, P=0.049). In addition, we observed an increased risk in OA cases, compared with controls, in the overall analysis (SMD=0.47, P=0.004) and subsequent subgroup analysis of "knee OA" (SMD=0.86, P<0.001), "Asian/China" (SMD=0.76, P=0.003), "cartilage-Asian/China" (SMD=1.21, P<0.001), and "synovial fluid-Asian/China" (SMD=0.73, P=0.004). In summary, a high protein level of MMP-1 in synovial fluid may be associated with the susceptibility to RA, and the high MMP-1 level in the cartilage tissue or synovial fluid may be related to the pathogenesis of knee OA in the Chinese population. This should be confirmed by larger sample sizes.

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Figures

Figure 1
Figure 1. Flowchart of study identification. RA: rheumatoid arthritis; OA: osteoarthritis.
Figure 2
Figure 2. Subgroup analysis by sample source for rheumatoid arthritis (RA) risk. See Supplementary Table S1 for reference numbers.
Figure 3
Figure 3. Subgroup analysis by ethnicity for osteoarthritis (OA) risk. See Supplementary Table S1 for reference numbers.
Figure 4
Figure 4. Subgroup analysis by sample source for osteoarthritis (OA) risk. See Supplementary Table S1 for reference numbers.
Figure 5
Figure 5. Aand B, sensitivity analysis; C and D, Egger's publication bias plot data. RA: rheumatoid arthritis; OA: osteoarthritis. See Supplementary Table S1 for reference numbers.
See this image and copyright information in PMC

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