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Comment
. 2020 Dec 17;136(25):2847-2848.
doi: 10.1182/blood.2020009408.

Expanding the toolbox to combat a pandemic

Susan E Prockop  1
Affiliations
Comment

Expanding the toolbox to combat a pandemic

Susan E Prockop. Blood. .

Abstract

Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for optimizing treatment of COVID-19. In this issue of Blood, Keller and colleagues generated SARS-CoV-2–specific cytotoxic T lymphocytes (CTLs) from the blood of individuals recovered from infection. The rapid application of this good manufacturing practice (GMP)-compliant system raises the possibility that banked third-party SARS-CoV-2 CTLs could be used for treatment.

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Conflict of interest statement

Conflict-of-interest disclosure: The author receives support for the conduct of sponsored trials from Atara Biotherapeutics, Mesoblast, and Jasper, is an inventor of IP licensed to Atara Biotherapeutics by MSKCC, has assigned all rights to MSKCC, and has no financial interest in Atara Biotherapeutics.

Conflict-of-interest disclosure: The author receives support for the conduct of sponsored trials from Atara Biotherapeutics, Mesoblast, and Jasper, is an inventor of IP licensed to Atara Biotherapeutics by MSKCC, has assigned all rights to MSKCC, and has no financial interest in Atara Biotherapeutics.

Comment on

  • SARS-CoV-2-specific T cells are rapidly expanded for therapeutic use and target conserved regions of the membrane protein.
    Keller MD, Harris KM, Jensen-Wachspress MA, Kankate VV, Lang H, Lazarski CA, Durkee-Shock J, Lee PH, Chaudhry K, Webber K, Datar A, Terpilowski M, Reynolds EK, Stevenson EM, Val S, Shancer Z, Zhang N, Ulrey R, Ekanem U, Stanojevic M, Geiger A, Liang H, Hoq F, Abraham AA, Hanley PJ, Cruz CR, Ferrer K, Dropulic L, Gangler K, Burbelo PD, Jones RB, Cohen JI, Bollard CM. Keller MD, et al. Blood. 2020 Dec 17;136(25):2905-2917. doi: 10.1182/blood.2020008488. Blood. 2020. PMID: 33331927 Free PMC article.

References

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