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Review
. 2020;26(4):17-22.
doi: 10.33529/ANGI02020406.

[Mönkeberg's sclerosis: role of calcification in arterial lesions in patients with diabetes mellitus]

[Article in Russian]
A N Kulikova  1 , A S Tolstokorov  2 , I V Larin  2
Affiliations
Review

[Mönkeberg's sclerosis: role of calcification in arterial lesions in patients with diabetes mellitus]

[Article in Russian]
A N Kulikova et al. Angiol Sosud Khir. 2020.

Abstract
in English, Russian

The number of patients with diabetes mellitus has steadily been increasing. This disease is associated with the risk for the development of micro- and macroangiopathies. One of the variants of macroangiopathy is Mönkeberg's sclerosis characterized by the presence of calcification of the media of the arterial wall. This article is a literature review reflecting the role of calcification in arterial lesions in patients with diabetes mellitus, also covering the historical aspect of studying Mönkeberg's sclerosis. Special attention is paid to its morphological forms, aetiopathogenetic mechanisms of development, taking into account contemporary studies, demonstrating mechanisms of the effect of medial arterial calcification on haemodynamics and the risk for the development of cardiovascular complications. Also presented herein are the main non-invasive and invasive methods of its diagnosis.

Неуклонно растет число больных сахарным диабетом. Данное заболевание сопряжено с риском развития микро- и макроангиопатий. Одним из вариантов макроангиопатии является склероз Менкеберга, характеризующийся наличием кальциноза медии артериальной стенки. В данном литературном обзоре отражена роль кальциноза в поражении артерий у больных сахарным диабетом. Освещен исторический аспект изучения склероза Менкеберга. Особое внимание уделено его морфологическим формам, этиопатогенетическим механизмам развития с учетом современных исследований. Показаны механизмы влияния медиакальциноза артерий на гемодинамику и риск развития сердечно-сосудистых осложнений. В обзоре представлены основные неинвазивные и инвазивные методы его диагностики.

Keywords: Mönkeberg’s sclerosis; atherosclerosis; calcification; cardiovascular complications; diabetes mellitus.

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References

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    1. Mönckeberg JG. Über die reine Mediaverkalkung der Extremitätenarterien und ihr Verhalten zur Arteriosklerose. Virchows. Arch. Pathol. Anat. 1903; 171: 141–167.
    1. Faber A. Die Arteriosklerose, ihre pathologische Anatomie, ihre Pathogenese und Aetiologie. Jena: G. Fisher. 1912; 186.
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    1. Guzman RJ. Clinical, cellular, and molecular aspects of arterial calcification. J. Vasc. Surg. 2007; 45: 57–63. doi: 10.1016/j.jvs.2007.02.049

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