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. 2021 Feb;56(2):384-391.
doi: 10.1002/ppul.25212. Epub 2020 Dec 17.

Variability in care for children with severe acute asthma in Latin America

Nicolas Monteverde-Fernandez  1   2 , Franco Diaz-Rubio  1   3   4 , Pablo Vásquez-Hoyos  1   5   6   7 , Alexandre T Rotta  8 , Sebastián González-Dambrauskas  1   9 ; LARed Network
Affiliations

Variability in care for children with severe acute asthma in Latin America

Nicolas Monteverde-Fernandez et al. Pediatr Pulmonol. 2021 Feb.

Abstract

Background: Care variability for children with severe acute asthma has been well documented in high-income countries, yet data from low- and middle-income regions are lacking. We sought to characterize the magnitude of practice variability in the care of Latin American children to identify opportunities for standardization of care.

Methods: A cross-sectional study performed through a retrospective analysis of contemporaneously collected data of children with severe acute asthma admitted to a center contributing to the LARed Network registry between May 2017 and May 2019. Centers were grouped by geographic location: Atlantic (AT), South Pacific (SP), and North Central (NC).

Results: Among 434 children, most received care in hospitals in the AT group (54% [235/434]), followed by the NC (23% [101/434]) and SP (23% [98/434]) groups. The majority of children in the AT (92% [215/235]) and SP (91% [89/98]) groups received nebulized salbutamol/albuterol, while metered-dose inhalers were preferred in the NC group (72% [73/101]). There was a wide variation in the use of antibiotics: AT (57% [135/235]), SP (48% [47/98]), and NC (14% [14/101]). The same was true for ipratropium bromide: AT (67% [157/235]), SP (90% [88/98]), and NC (17% [17/101]), and aminophylline: AT (57% [135/235]), NC (5% [5/101]), and SP (0% [0/98]). High-flow nasal cannula was the preferred respiratory support modality in the AT (60% [141/235]) and NC (40% [40/101]) groups, while bilevel positive airway pressure (BiPAP) use was more common in the SP group (80% [78/98]).

Conclusion: We identified significant variability in care for severe acute asthma. Our findings will help to inform the design of future studies, quality improvement initiatives, and development of practice guidelines within Latin America.

Keywords: asthma; asthma acute exacerbation; children; severe acute asthma; status asthmaticus.

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References

REFERENCES

    1. Akinbami LJ, Moorman JE, Bailey C, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief. 2012;(94):1-8.
    1. Asher MI, Montefort S, Bjorksten B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733-743.
    1. Ocampo J, Gaviria R, Sanchez J. Prevalence of asthma in Latin America. Critical look at ISAAC and other studies. Rev Alerg Mex. 2017;64(2):188-197.
    1. Hasegawa K, Tsugawa Y, Brown DF, Camargo CA Jr. Childhood asthma hospitalizations in the United States, 2000-2009. J Pediatr. 2013;163(4):1127-1133.
    1. Hartman ME, Linde-Zwirble WT, Angus DC, Watson RS. Trends in admissions for pediatric status asthmaticus in New Jersey over a 15-year period. Pediatrics. 2010;126(4):e904-e911.