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Review
. 2020 Mar 19;7(4):598-605.
doi: 10.1016/j.gendis.2020.03.005. eCollection 2020 Dec.

The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He  1   2 , Jing Jiang  2   3 , Di-Xian Luo  2   3
Affiliations
Review

The functions of N6-methyladenosine modification in lncRNAs

Rong-Zhang He et al. Genes Dis. .

Abstract

Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA. Extensive studies of m6A modification of mRNAs have been carried out, while little is known about m6A modification of long non-coding RNAs (lncRNAs). Recently, several studies reported m6A modification of lncRNAs. In this review, we focus on these m6A-modified lncRNAs and discuss possible functions of m6A modification.

Keywords: Erasers; LncRNA; N6-methyladenosine; Readers; Writers.

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Figures

Figure 1
Figure 1
N6-methyladenosine modification of MALAT1.
Figure 2
Figure 2
N6-methyladenosine modification of XIST.
Figure 3
Figure 3
N6-methyladenosine modification of lncRNA RP11.
Figure 4
Figure 4
N6-methyladenosine modification of FAM225A.
Figure 5
Figure 5
N6-methyladenosine modification of GAS5.
See this image and copyright information in PMC

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References

    1. Li T., Hu P.S., Zuo Z. Mettl3 facilitates tumor progression via an m(6)a-igf2bp2-dependent mechanism in colorectal carcinoma. Mol Canc. 2019;18:112. - PMC - PubMed
    1. Xu C.L., Sang B., Liu G.Z. Senebloc, a long non-coding rna suppresses senescence via p53-dependent and independent mechanisms. Nucleic Acids Res. 2020 [Epub ahead of print] - PMC - PubMed
    1. Keihani S., Kluever V., Mandad S. The long noncoding rna neurolnc regulates presynaptic activity by interacting with the neurodegeneration-associated protein tdp-43. Sci Adv. 2019;5 - PMC - PubMed
    1. Hu Y.P., Jin Y.P., Wu X.S. Lncrna-hgbc stabilized by hur promotes gallbladder cancer progression by regulating mir-502-3p/set/akt axis. Mol Canc. 2019;18:167. - PMC - PubMed
    1. Tang J., Yan T., Bao Y. Lncrna glcc1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-myc. Nat Commun. 2019;10:3499. - PMC - PubMed

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