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. 2020 Jun 1:9:37-45.
doi: 10.1016/j.ibror.2020.05.001. eCollection 2020 Dec.

Does calorie restriction improve cognition?

Isabella Rocha Dias  1   2 , Carina de Sousa Santos  2 , Caíque Olegário Diniz E Magalhães  1   2 , Lucas Renan Sena de Oliveira  1   2 , Marco Fabrício Dias Peixoto  3   1   2   4 , Ricardo Augusto Leoni De Sousa  1   2 , Ricardo Cardoso Cassilhas  3   1   2   4
Affiliations

Does calorie restriction improve cognition?

Isabella Rocha Dias et al. IBRO Rep. .

Abstract

Calorie restriction (CR) has been considered the most effective non-pharmacological intervention to counteract aging-related diseases and improve longevity. This intervention has shown beneficial effects in the prevention and treatment of several chronic diseases and functional declines related to aging, such as Parkinson's, Alzheimer's, and neuroendocrine disorders. However, the effects of CR on cognition show controversial results since its effects vary according to intensity, duration, and the period of CR. This review focuses on the main studies published in the last ten years regarding the consequences of CR on cognition in different neurological diseases and conditions of experimental animals. Also, possible CR mimetics are discussed. These findings highlight the potential beneficial effects of CR of up to 40 % on cognition when started early in life in non human animals.

Keywords: Aging; Calorie intake; Cognitive function; Memory; Neurodegenative diseases.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Methodological flowchart.
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