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Review
. 2021 Feb;93(2):e13012.
doi: 10.1111/sji.13012. Epub 2021 Jan 6.

The role of Interleukin-32 in autoimmunity

Rafael de Albuquerque  1 , Elina Komsi  1 , Inna Starskaia  1 , Ubaid Ullah  1 , Riitta Lahesmaa  1
Affiliations
Free article
Review

The role of Interleukin-32 in autoimmunity

Rafael de Albuquerque et al. Scand J Immunol. 2021 Feb.
Free article

Abstract

Interleukin-32 (IL-32) is a pro-inflammatory cytokine that induces other cytokines involved in inflammation, including tumour necrosis factor (TNF)-α, IL-6 and IL-1β. Recent evidence suggests that IL-32 has a crucial role in host defence against pathogens, as well as in the pathogenesis of chronic inflammation. Abnormal IL-32 expression has been linked to several autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel diseases, and a recent study suggested the importance of IL-32 in the pathogenesis of type 1 diabetes. However, despite accumulating evidence, many molecular characteristics of this cytokine, including the secretory route and the receptor for IL-32, remain largely unknown. In addition, the IL-32 gene is found in higher mammals but not in rodents. In this review, we outline the current knowledge of IL-32 biological functions, properties, and its role in autoimmune diseases. We particularly highlight the role of IL-32 in rheumatoid arthritis and type 1 diabetes.

Keywords: Interleukin-32; rheumatoid arthritis; type 1 diabetes.

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References

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