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. 2020 Dec 21:54:e02522020.
doi: 10.1590/0037-8682-0252-2020. eCollection 2020.

AIDS-related progressive multifocal leukoencephalopathy

Carolina de Oliveira Abrão  1 , Lissa Rodrigues Machado da Silva  1 , Luiz Carlos Silva Souza  1   2 , Nathalia de Mello Bisso  1 , Marília Dalva Turchi  2 , Adriana Oliveira Guilarde  2
Affiliations

AIDS-related progressive multifocal leukoencephalopathy

Carolina de Oliveira Abrão et al. Rev Soc Bras Med Trop. .

Abstract

Introduction: Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by reactivation of JC virus (JCV).

Methods: We described the profile of laboratory-confirmed PML cases among AIDS patients.

Results: A total of 43 HIV patients with clinical conditions compatible with PML were obtained; 5 cases were confirmed by JCV testing. The main clinical finding was mental confusion. Median CD4 count was 54 cells/mm³.

Conclusions: Three of the five confirmed PML cases died; the time between diagnosis and death was 2, 5, and 6 months. It is important to consider JCV infection as a differential diagnosis.

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Conflict of interest statement

Conflicts of interest: The authors declare to have no conflicts of interest.

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