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Case Reports
. 2020 Dec 21:54:e20200143.
doi: 10.1590/0037-8682-0143-2020. eCollection 2020.

Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation

Claudia Marcela Chalela  1 , Angela Maria Peña  1   2 , Angela Maria Roa  1 , David L Reyes  1 , Jennifer Paola Rueda  1 , Luis Antonio Salazar  1   2 , Manuel Rosales  2 , Edgar David Gomez  1   3 , Edgar Augusto Bernal  4 , Claudia Lucia Sossa Melo  1   2
Affiliations
Case Reports

Reactivation of Chagas disease after autologous hematopoietic stem cell transplantation

Claudia Marcela Chalela et al. Rev Soc Bras Med Trop. .

Abstract

Chagas disease (CD) is a protozoan zoonosis caused by Trypanosoma cruzi. Reactivation of CD occurs via drug-induced immunosuppression before and during transplantation. Here, we report the case of a 62-year-old man diagnosed with classic Hodgkin lymphoma who received highly aggressive conditioning chemotherapy before undergoing stem cell transplantation (SCT). The patient tested positive for CD in pre-transplantation evaluation. The patient exhibited persistent fever and elevated C-reactive protein levels before and after SCT, and was treated with antibiotics. Micro-Strout test showed evidence of trypomastigotes and he was treated with benznidazole until tested negative. Post-transplantation seropositive patients should be screened for possible reactivation.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

FIGURE 1:
FIGURE 1:. Micro-Strout test of the patient depicting trypomastigotes in peripheral blood sample.
See this image and copyright information in PMC

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