Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency
- PMID: 33338408
- DOI: 10.1016/j.molcel.2020.11.042
Formaldehyde Causes Bone Marrow Failure Linked to Transcriptional Reprogramming or Metabolic Deficiency
Abstract
Two new studies in this issue of Molecular Cell demonstrate that bone marrow failure, in mice and humans, can be induced by formaldehyde generated either from defective metabolism (Dingler et al., 2020) or during the process of transcriptional reprogramming (Shen et al., 2020).
Copyright © 2020 Elsevier Inc. All rights reserved.
Comment on
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Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.Mol Cell. 2020 Dec 17;80(6):996-1012.e9. doi: 10.1016/j.molcel.2020.10.012. Epub 2020 Nov 3. Mol Cell. 2020. PMID: 33147438 Free PMC article.
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A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia.Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. Mol Cell. 2020. PMID: 33338401 Free PMC article.
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