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. 2021 Mar;74(3):748-749.
doi: 10.1016/j.jhep.2020.12.007. Epub 2020 Dec 16.

Increased expression of key SARS-CoV-2 entry points in multiple tissues in individuals with NAFLD

Abraham S Meijnikman  1 , Sjoerd Bruin  2 , Albert K Groen  3 , Max Nieuwdorp  3 , Hilde Herrema  4
Affiliations

Increased expression of key SARS-CoV-2 entry points in multiple tissues in individuals with NAFLD

Abraham S Meijnikman et al. J Hepatol. 2021 Mar.
No abstract available

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Conflict of interest statement

Conflict of interest The authors declare no conflict of interest. Please refer to the accompanying ICMJE disclosure forms for further details.

Figures

Fig. 1
Fig. 1
SARS-CoV-2 entry point expression in patients with and without NAFLD. (A) Insulin and (B) glucose excursions during the MMT. (C–F) ACE2 expression in individuals with and without NAFLD in different tissues. (G–J) TMPRSS2 expression in individuals with and without NAFLD in different tissues. (K) Pearson correlation between hepatic ACE2 and TMPRSS2 expression. (L) Pearson correlation between hepatic ACE2 expression and insulin AUC determined during the MMT. Pearson correlation between hepatic ACE2 expression and glucose AUC determined during the MMT. For comparison between gene expression levels Mann-Whitney U test was used. ACE2, angiotensin converting enzyme 2; AUC, area under the curve; MMT, mixed meal tolerance test; NAFLD, non-alcoholic fatty liver disease; SAT, subcutaneous adipose tissue; TMPRSS2, transmembrane protease serine 2; VAT, visceral adipose tissue.
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