Centrosome organization and functions

Abstract

The centrosome, discovered near 1875, was named by Boveri when proposing the chromosomal theory of heredity. After a long eclipse, a considerable amount of molecular data has been accumulated on the centrosome and its biogenesis in the last 30 years, summarized regularly in excellent reviews. Major questions are still at stake in 2021 however, as we lack a comprehensive view of the centrosome functions. I will first try to see how progress towards a unified view of the role of centrosomes during evolution is possible, and then review recent data on only some of the many important questions raised by this organelle.