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Case Reports
. 2020 Dec 18;14(1):246.
doi: 10.1186/s13256-020-02595-3.

Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report

Maria Chiara Pelle  1 , Bruno Tassone  2 , Marco Ricchio  2 , Maria Mazzitelli  2 , Chiara Davoli  2 , Giada Procopio  2 , Anna Cancelliere  2 , Valentina La Gamba  2 , Elena Lio  2 , Giovanni Matera  3 , Angela Quirino  3 , Giorgio Settimo Barreca  4 , Enrico Maria Trecarichi  2 , Carlo Torti  2 ; IDTM UMG COVID-19 Group
Collaborators, Affiliations
Case Reports

Late-onset myocardial infarction and autoimmune haemolytic anaemia in a COVID-19 patient without respiratory symptoms, concomitant with a paradoxical increase in inflammatory markers: a case report

Maria Chiara Pelle et al. J Med Case Rep. .

Abstract

Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.

Case presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.

Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).

Keywords: AIHA; Anaemia; COVID-19; Cardiovascular disease; IL-6; Inflammation.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Baseline electrocardiogram (a) and the occurrence of myocardial infarction (b)
See this image and copyright information in PMC

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