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. 1977 Sep;4(9):3267-79.
doi: 10.1093/nar/4.9.3267.

Structure of chromatin subunits: an endonuclease Serratia marcescens study

V A Pospelov, S B Svetlikova, V I Vorob'ev
Free PMC article

Structure of chromatin subunits: an endonuclease Serratia marcescens study

V A Pospelov et al. Nucleic Acids Res. 1977 Sep.
Free PMC article

Abstract

Electrophoretic properties of chromatin subunits--nucleosomes--obtained by treatment of chromatin with the Serratia marcescens endonuclease have been studied. Double-stranded breaks of DNA between adjacent nucleosomes do not necessarily lead to their disjunction. Fragmentation of the DNA within the nucleosomes may proceed simultaneously with the breakdown of the DNA between the nucleosomes at early stages of the endonuclease digestion. Electrophoretic mobility and chromatographic properties of mononucleosomes, their dimers and trimers with internally degraded DNA was not changed. It has been deduced that the integrity of chromatin particles with internally fragmented DNA is supported by histone interaction inside and between the nucleosomes.

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References

    1. FEBS Lett. 1977 Mar 1;74(2):229-33 - PubMed
    1. Nature. 1976 Dec 9;264(5586):517-22 - PubMed
    1. Annu Rev Biochem. 1975;44:725-74 - PubMed
    1. Biochemistry. 1967 Jun;6(6):1818-27 - PubMed
    1. Science. 1974 Jan 25;183(4122):330-2 - PubMed