Conflict of interest Christophe Moreno was paid as consultant for Abbvie, Astellas, Bayer, Gilead Sciences, Norgine, Novartis; Nick Sheron: Clinical adviser to Public Health England. Other advisory work: Alcohol Health Alliance UK, UK Department of Health, Home Office, British Liver Trust, European Public Health Alliance, European Society for the Study of Liver Disease, British Society for the Study of Liver Disease. Consultancy work and travelling expenses from pharmaceutical companies: Norgine and Kyowa Kirin Limited, Gilead; Dina Tiniakos: nothing to declare; Carolin Lackner was paid as consultant for Allergan, Verily, Histoindex, Dr. Falk Pharma GmbH, Galmed Research and Development Ltd; Philippe Mathurin was paid as consultant for Sanofi, Gilead Sciences, Novo Nordisk, Intercept, Generon. Please refer to the accompanying ICMJE disclosure forms for further details.