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Comment
. 2021 Jan:93:102329.
doi: 10.1016/j.ceca.2020.102329. Epub 2020 Dec 8.

Lactate as a new second messenger shaping intracellular Mg2+ dynamics and bioenergetics

Vladimir Chubanov  1 , Thomas Gudermann  2
Affiliations
Comment

Lactate as a new second messenger shaping intracellular Mg2+ dynamics and bioenergetics

Vladimir Chubanov et al. Cell Calcium. 2021 Jan.

Abstract

Mg2+ is an essential cation controlling many biochemical reactions. Recently, Daw et al. [1] have shown that l-lactate acts as a second messenger triggering a dynamic exchange of Mg2+ between the endoplasmic reticulum and mitochondria to shape energy metabolism. This discovery changes our view on the cellular role of Mg2+.

Keywords: Bioenergetics; Lactate; Mg(2+); Mitochondria; Mrs2.

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Comment on

  • Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism.
    Daw CC, Ramachandran K, Enslow BT, Maity S, Bursic B, Novello MJ, Rubannelsonkumar CS, Mashal AH, Ravichandran J, Bakewell TM, Wang W, Li K, Madaris TR, Shannon CE, Norton L, Kandala S, Caplan J, Srikantan S, Stathopulos PB, Reeves WB, Madesh M. Daw CC, et al. Cell. 2020 Oct 15;183(2):474-489.e17. doi: 10.1016/j.cell.2020.08.049. Epub 2020 Oct 8. Cell. 2020. PMID: 33035451 Free PMC article.

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