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Review
. 2020;27(2):80-86.
doi: 10.1159/000513198. Epub 2020 Dec 18.

Hyperinflammation and Immune Response Generation in COVID-19

Kamla Prasad Mishra  1 , Ajay Kumar Singh  1 , Shashi Bala Singh  2
Affiliations
Review

Hyperinflammation and Immune Response Generation in COVID-19

Kamla Prasad Mishra et al. Neuroimmunomodulation. 2020.

Abstract

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. The pathophysiology of this virus is not very clearly known, thus, enormous efforts are being made by the scientific community to delineate its evading mechanism. In this review, we have summarized the hyperinflammation and humoral and cell-mediated immune response generated in human body after infection with the SARS-CoV-2 virus. The inflammatory response generated after infection by increased proinflammatory cytokines and chemokines, and complement proteins activation may likely contribute to disease severity. We also discussed the other factors that may affect immunity and could be important comorbidities in the disease severity and outcome.

Keywords: COVID-19; Cytokine; Immunity; Inflammation; SARS-CoV-2.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Annotation of SARS-CoV-2 proteins. SARS, severe acute respiratory syndrome; CoV, coronavirus.
Fig. 2
Fig. 2
Immune response generation in COVID-19. COVID-19, coronavirus disease.
See this image and copyright information in PMC

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