Molecular mechanisms of anticancer activities of polyphyllin VII

doi:10.1111/cbdd.13818

Review

. 2021 Apr;97(4):914-929.

doi: 10.1111/cbdd.13818. Epub 2021 Jan 7.

Molecular mechanisms of anticancer activities of polyphyllin VII

Bashir Ahmad^{1

2}, Shafiq Ur Rehman¹, Azizullah Azizullah¹, Muhammad Fiaz Khan³, Syed Riaz Ud Din², Manzoor Ahmad⁴, Ashraf Ali⁵, Naeem Tahir², Nasir Azam², Yaser Gamallat⁶, Khalil Ur Rahman², Muhsin Ali², Mohammad Safi⁷, Imran Khan⁸, Samina Qamer⁹, Deog-Hwan Oh¹⁰

Affiliations

¹ Department of Biology (Botany, Zoology, Biochemistry), The University of Haripur, Haripur, Pakistan.
² College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
³ Zoology Department, Hazara University, Mansehra, Pakistan.
⁴ Department of Chemistry, Malakand University, Chakdara, Pakistan.
⁵ Department of Chemistry, The University of Haripur, Haripur, Pakistan.
⁶ Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China.
⁷ Oncology Department First affiliated Hospital of Dalian Medical University, Dalian, China.
⁸ Department of Food Science and Technology, The University of Haripur, Haripur, Pakistan.
⁹ Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan.
¹⁰ Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, South Korea.

PMID: 33342040
DOI: 10.1111/cbdd.13818

Review

Molecular mechanisms of anticancer activities of polyphyllin VII

Bashir Ahmad et al. Chem Biol Drug Des. 2021 Apr.

. 2021 Apr;97(4):914-929.

doi: 10.1111/cbdd.13818. Epub 2021 Jan 7.

Authors

Affiliations

¹ Department of Biology (Botany, Zoology, Biochemistry), The University of Haripur, Haripur, Pakistan.
² College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
³ Zoology Department, Hazara University, Mansehra, Pakistan.
⁴ Department of Chemistry, Malakand University, Chakdara, Pakistan.
⁵ Department of Chemistry, The University of Haripur, Haripur, Pakistan.
⁶ Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China.
⁷ Oncology Department First affiliated Hospital of Dalian Medical University, Dalian, China.
⁸ Department of Food Science and Technology, The University of Haripur, Haripur, Pakistan.
⁹ Department of Zoology, Government College University Faisalabad, Faisalabad, Pakistan.
¹⁰ Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, South Korea.

PMID: 33342040
DOI: 10.1111/cbdd.13818

Abstract

Cancer is the leading cause of mortality in the world. The major therapies for cancer treatment are chemotherapy, surgery, and radiation therapy. All these therapies expensive, toxic and show resistance. The plant-derived compounds are considered safe, cost-effective and target cancer through different pathways. In these pathways include oxidative stress, mitochondrial dependent and independent, STAT3, NF-kB, MAPKs, cell cycle, and autophagy pathways. One of the new plants derived compounds is Polyphyllin VII (PPVII), which target cancer through different molecular mechanisms. In literature, there is a review gap of studies on PPVII; therefore in the current review, we summarized the available studies on PPVII to provide a base for future research.

Keywords: Polyphyllin VII; STAT3; cancer; chemotherapy; radiation therapy; surgery.

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References

REFERENCES

1. Ahmad, A., Sarkar, S. H., Aboukameel, A., Ali, S., Biersack, B., Seibt, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Schobert, R., Padhye, S. B., & Sarkar, F. H. (2012). Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis, 33(12), 2450-2456. https://doi.org/10.1093/carcin/bgs290
1. Ahmad, A., Sarkar, S. H., Bitar, B., Ali, S., Aboukameel, A., Sethi, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Padhye, S. B., & Sarkar, F. H. (2012). Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Molecular Cancer Therapeutics, 11(10), 2193-2201. https://doi.org/10.1158/1535-7163.mct-12-0232-t
1. Ahmad, A., Wang, Z., Ali, R., Maitah, M. Y., Kong, D., Banerjee, S., Padhye, S., & Sarkar, F. H. (2010). Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. Journal of Cellular Biochemistry, 109(6), 1134-1141. https://doi.org/10.1002/jcb.22492
1. Ahmad, B., Gamallat, Y., Su, P., Husain, A., Rehman, A. U., Zaky, M. Y., Bakheet, A. M. H., Tahir, N., Xin, Y., &Liang, W. (2020). Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical Biology & Drug Design, 96(2), 1-7.
1. Ahmad, B., Khan, S., Liu, Y., Xue, M., Nabi, G., Kumar, S., Alshwmi, M., & Qarluq, A. W. (2020). Molecular mechanisms of anticancer activities of puerarin. Cancer Management and Research, 12, 79-90. https://doi.org/10.2147/CMAR.S233567

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[1] Ahmad, A., Sarkar, S. H., Aboukameel, A., Ali, S., Biersack, B., Seibt, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Schobert, R., Padhye, S. B., & Sarkar, F. H. (2012). Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis, 33(12), 2450-2456. https://doi.org/10.1093/carcin/bgs290

[2] Ahmad, A., Sarkar, S. H., Aboukameel, A., Ali, S., Biersack, B., Seibt, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Schobert, R., Padhye, S. B., & Sarkar, F. H. (2012). Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling. Carcinogenesis, 33(12), 2450-2456. https://doi.org/10.1093/carcin/bgs290

[3] Ahmad, A., Sarkar, S. H., Bitar, B., Ali, S., Aboukameel, A., Sethi, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Padhye, S. B., & Sarkar, F. H. (2012). Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Molecular Cancer Therapeutics, 11(10), 2193-2201. https://doi.org/10.1158/1535-7163.mct-12-0232-t

[4] Ahmad, A., Sarkar, S. H., Bitar, B., Ali, S., Aboukameel, A., Sethi, S., Li, Y., Bao, B., Kong, D., Banerjee, S., Padhye, S. B., & Sarkar, F. H. (2012). Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Molecular Cancer Therapeutics, 11(10), 2193-2201. https://doi.org/10.1158/1535-7163.mct-12-0232-t

[5] Ahmad, A., Wang, Z., Ali, R., Maitah, M. Y., Kong, D., Banerjee, S., Padhye, S., & Sarkar, F. H. (2010). Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. Journal of Cellular Biochemistry, 109(6), 1134-1141. https://doi.org/10.1002/jcb.22492

[6] Ahmad, A., Wang, Z., Ali, R., Maitah, M. Y., Kong, D., Banerjee, S., Padhye, S., & Sarkar, F. H. (2010). Apoptosis-inducing effect of garcinol is mediated by NF-kappaB signaling in breast cancer cells. Journal of Cellular Biochemistry, 109(6), 1134-1141. https://doi.org/10.1002/jcb.22492

[7] Ahmad, B., Gamallat, Y., Su, P., Husain, A., Rehman, A. U., Zaky, M. Y., Bakheet, A. M. H., Tahir, N., Xin, Y., &Liang, W. (2020). Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical Biology & Drug Design, 96(2), 1-7.

[8] Ahmad, B., Gamallat, Y., Su, P., Husain, A., Rehman, A. U., Zaky, M. Y., Bakheet, A. M. H., Tahir, N., Xin, Y., &Liang, W. (2020). Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway. Chemical Biology & Drug Design, 96(2), 1-7.

[9] Ahmad, B., Khan, S., Liu, Y., Xue, M., Nabi, G., Kumar, S., Alshwmi, M., & Qarluq, A. W. (2020). Molecular mechanisms of anticancer activities of puerarin. Cancer Management and Research, 12, 79-90. https://doi.org/10.2147/CMAR.S233567

[10] Ahmad, B., Khan, S., Liu, Y., Xue, M., Nabi, G., Kumar, S., Alshwmi, M., & Qarluq, A. W. (2020). Molecular mechanisms of anticancer activities of puerarin. Cancer Management and Research, 12, 79-90. https://doi.org/10.2147/CMAR.S233567

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Molecular mechanisms of anticancer activities of polyphyllin VII

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Molecular mechanisms of anticancer activities of polyphyllin VII

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