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. 2020 Oct 30;50(5):264-270.
doi: 10.4274/tjo.galenos.2020.18488.

Agreement Between Standard Optical Coherence Tomography and Optical Coherence Tomography-Based Angiography in Estimating Retinal Nerve Fiber Layer Thickness

Hayati Yılmaz  1 , Mehmet Talay Köylü  2 , Alper Can Yılmaz  2 , Ali Hakan Durukan  2 , Yusuf Uysal  2
Affiliations

Agreement Between Standard Optical Coherence Tomography and Optical Coherence Tomography-Based Angiography in Estimating Retinal Nerve Fiber Layer Thickness

Hayati Yılmaz et al. Turk J Ophthalmol. .

Abstract

Objectives: To investigate the agreement between optical coherence tomography (OCT) and OCT-based angiography (OCT-A) in estimating retinal nerve fiber layer thickness (RNFLT) and evaluate the associations between peripapillary vessel density (VD) and RNFLT measurements obtained with both devices.

Materials and methods: The AngioVue (Optovue Inc., Fremont, CA, USA) and Spectralis (Heidelberg Engineering, Heidelberg, Germany) images of 325 patients were screened retrospectively. RNFLT values were recorded using both devices. The intraclass correlation coefficient (ICC) and Bland-Altman plots were obtained to investigate the agreement between the devices. Age- and intraocular pressure-corrected associations between VD and RNFLT measured by the two devices were analyzed using linear regression models.

Results: ICC revealed excellent agreement for global, superior, inferior, and temporal RNFLT and good agreement for the nasal quadrant (ICC=0.895, 0.936, 0.923, 0.887, and 0.614, respectively). The Bland-Altman plots showed poor agreement for all measurements with a large span of limits of agreement and significant proportional bias (p<0.05). VD was found to be strongly associated with the RNFLT measurements of both devices (p<0.001).

Conclusion: The disagreement between the devices should be considered in clinical practice, and the data should not be used interchangeably. The association of the peripapillary VD with RNFLT using both devices indicated that RNFLT assessed by the AngioVue could be used in glaucoma management along with VD.

Keywords: Glaucoma; agreement; angiography; coherence; optical.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Scatter plots of AngioVue versus Spectralis OCT for RNFLT (column 1) and the Bland-Altman plots for the agreement between AngioVue and Spectralis for the RNFLT (column 2). Scatter plots were given with the regression line (black line) and the 95% limits of agreements (red lines). Bland-Altman plots were given with the mean of the difference (red bold line), 1.96 SDs (black bold lines), and the regression lines (black thin lines). RNFLT scatter and Bland-Altman plots for global (a1,a2), superior (b1,b2), nasal (c1,c2), inferior (d1,d2), temporal (e1,e2) RNFLT values OCT: Optical coherence tomography, RNFLT: Retinal nerve fiber layer thickness, SD: Standard deviation
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